| http://purl.uniprot.org/citations/9443401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9443401 | http://www.w3.org/2000/01/rdf-schema#comment | "Hemizygous germ-line defects in mismatch repair (MMR) genes underlie hereditary nonpolyposis colorectal cancer (HNPCC). Loss of the wild-type allele results in a mutator phenotype, accelerating tumorigenesis. Tumorigenesis specifically occurs in the gastrointestinal and genitourinary tracts; the cause of this tissue specificity is elusive. To understand the etiology and tissue distribution of tumors in HNPCC, we have developed mouse models carrying a deficiency in the MMR gene Msh2. Most of the completely Msh2-deficient mice succumbed to lymphomas at an early age; lymphomagenesis was synergistically enhanced by exposure to ethylnitrosourea. Lymphomas were absent in immunocompromised Tap1-/-;Msh2-/-mice; these mice generally succumbed to HNPCC-like tumors. Together, these data suggest that the HNPCC tumor spectrum is determined by exposure of MMR-deficient cells to exogenous mutagens, rather than by tissue-specific loss of the wild-type MMR allele or by immune surveillance. Msh2 hemizygous mice had an elevated tumor incidence that, surprisingly, was rarely correlated with loss of the Msh2+ allele. To develop a model for intestinal tumorigenesis in HNPCC, we introduced the Min allele of the Apc tumor suppressor gene. We observed loss of the wild-type Msh2 allele in a significant fraction of intestinal tumors in Apc+/Min;Msh2+/-mice. In some of the latter tumors, one area of the tumor displayed loss of the Msh2+ allele, but not of the Apc+ allele, whereas another area displayed the inverse genotype. This apparent biclonality might indicate a requirement for collaboration between independent tumor clones during intestinal tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/9443401 | http://purl.uniprot.org/core/author | "de Wind N."xsd:string |
| http://purl.uniprot.org/citations/9443401 | http://purl.uniprot.org/core/author | "van der Valk M."xsd:string |
| http://purl.uniprot.org/citations/9443401 | http://purl.uniprot.org/core/author | "te Riele H."xsd:string |
| http://purl.uniprot.org/citations/9443401 | http://purl.uniprot.org/core/author | "Dekker M."xsd:string |
| http://purl.uniprot.org/citations/9443401 | http://purl.uniprot.org/core/author | "van Rossum A."xsd:string |
| http://purl.uniprot.org/citations/9443401 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9443401 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/9443401 | http://purl.uniprot.org/core/pages | "248-255"xsd:string |
| http://purl.uniprot.org/citations/9443401 | http://purl.uniprot.org/core/title | "Mouse models for hereditary nonpolyposis colorectal cancer."xsd:string |
| http://purl.uniprot.org/citations/9443401 | http://purl.uniprot.org/core/volume | "58"xsd:string |
| http://purl.uniprot.org/citations/9443401 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9443401 |
| http://purl.uniprot.org/citations/9443401 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9443401 |
| http://purl.uniprot.org/uniprot/P43247#attribution-1AD6212AE62AED2924DDE8C2DBC6DA2B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9443401 |
| http://purl.uniprot.org/uniprot/#_A0A068BER1-mappedCitation-9443401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9443401 |
| http://purl.uniprot.org/uniprot/#_B2RUG9-mappedCitation-9443401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9443401 |
| http://purl.uniprot.org/uniprot/#_E9QLQ9-mappedCitation-9443401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9443401 |
| http://purl.uniprot.org/uniprot/#_F6Z405-mappedCitation-9443401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9443401 |
| http://purl.uniprot.org/uniprot/#_P70382-mappedCitation-9443401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9443401 |
| http://purl.uniprot.org/uniprot/#_E9Q4H1-mappedCitation-9443401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9443401 |
| http://purl.uniprot.org/uniprot/#_F6Q4R2-mappedCitation-9443401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9443401 |
| http://purl.uniprot.org/uniprot/#_F6QHF1-mappedCitation-9443401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9443401 |
| http://purl.uniprot.org/uniprot/#_G3UWZ8-mappedCitation-9443401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9443401 |
| http://purl.uniprot.org/uniprot/#_G3UXD8-mappedCitation-9443401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9443401 |