| http://purl.uniprot.org/citations/9444325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9444325 | http://www.w3.org/2000/01/rdf-schema#comment | "Several genes involved in the determination of Listeria monocytogenes pathogenesis have been identified. Among them, plcA gene encodes phosphatidylinositol-specific phospholipase C (PI-PLC), plcB gene encodes a broad-range phospholipase C (PC-PLC), and actA encodes a protein contributing to actin assembly in infected cells. The interaction of L. monocytogenes wild type (LO 28) strain and two derivative mutants, plcA- (BUG 206) and actA-/plcB-(LUT 12), with macrophages and T lymphocytes was investigated in a mouse model of listeriosis. Both mutants showed evidence of attenuation. The plcA-mutant, but not the plcB-mutant, expressed an increase in susceptibility to the anti-listerial activity of macrophages. Both mutants showed a decreased ability to induce IL-12 production by bone marrow macrophages when co-stimulated with E. coli LPS or IFN-gamma. In vivo, L. monocytogenes plcA-mutant was found to be a more effective stimulator of T cells than the wild LO 28 strain."xsd:string |
| http://purl.uniprot.org/citations/9444325 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1348-0421.1997.tb01939.x"xsd:string |
| http://purl.uniprot.org/citations/9444325 | http://purl.uniprot.org/core/author | "Rudnicka W."xsd:string |
| http://purl.uniprot.org/citations/9444325 | http://purl.uniprot.org/core/author | "Szeliga J."xsd:string |
| http://purl.uniprot.org/citations/9444325 | http://purl.uniprot.org/core/author | "Kaczmarek M."xsd:string |
| http://purl.uniprot.org/citations/9444325 | http://purl.uniprot.org/core/author | "Germann T."xsd:string |
| http://purl.uniprot.org/citations/9444325 | http://purl.uniprot.org/core/author | "Rozalska B."xsd:string |
| http://purl.uniprot.org/citations/9444325 | http://purl.uniprot.org/core/author | "Wieckowska M."xsd:string |
| http://purl.uniprot.org/citations/9444325 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9444325 | http://purl.uniprot.org/core/name | "Microbiol Immunol"xsd:string |
| http://purl.uniprot.org/citations/9444325 | http://purl.uniprot.org/core/pages | "847-853"xsd:string |
| http://purl.uniprot.org/citations/9444325 | http://purl.uniprot.org/core/title | "The host response to Listeria monocytogenes mutants defective in genes encoding phospholipases C (plcA, plcB) and actin assembly (actA)."xsd:string |
| http://purl.uniprot.org/citations/9444325 | http://purl.uniprot.org/core/volume | "41"xsd:string |
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