| http://purl.uniprot.org/citations/9446639 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9446639 | http://www.w3.org/2000/01/rdf-schema#comment | "The erythroid-specific isoform of delta-aminolevulinate synthase (ALAS-E) catalyzes the first step of heme biosynthesis in erythroid cells, and ALAS-E gene mutations are known to be responsible for x-linked sideroblastic anemia. To study the role of ALAS-E in erythroid development, we prepared mouse embryonic stem (ES) cells carrying a disrupted ALAS-E gene and examined the effect of the lack of ALAS-E gene expression on erythroid differentiation. We found that mRNAs for erythroid transcription factors and TER119-positive cells were increased similarly both in the wild-type and mutant cells. In contrast, heme content, the number of benzidine-positive cells, adult globin protein, and mRNA for beta-major globin were significantly decreased in the mutant cells. These results were confirmed using another ES differentiation system in vitro and suggest that ALAS-E expression, hence heme supply, is critical for the late stage of erythroid cell differentiation, which involves hemoglobin synthesis."xsd:string |
| http://purl.uniprot.org/citations/9446639 | http://purl.uniprot.org/core/author | "Fujita H."xsd:string |
| http://purl.uniprot.org/citations/9446639 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/9446639 | http://purl.uniprot.org/core/author | "Nagai M."xsd:string |
| http://purl.uniprot.org/citations/9446639 | http://purl.uniprot.org/core/author | "Sassa S."xsd:string |
| http://purl.uniprot.org/citations/9446639 | http://purl.uniprot.org/core/author | "Harigae H."xsd:string |
| http://purl.uniprot.org/citations/9446639 | http://purl.uniprot.org/core/author | "Suwabe N."xsd:string |
| http://purl.uniprot.org/citations/9446639 | http://purl.uniprot.org/core/author | "Weinstock P.H."xsd:string |
| http://purl.uniprot.org/citations/9446639 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9446639 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/9446639 | http://purl.uniprot.org/core/pages | "798-805"xsd:string |
| http://purl.uniprot.org/citations/9446639 | http://purl.uniprot.org/core/title | "Deficient heme and globin synthesis in embryonic stem cells lacking the erythroid-specific delta-aminolevulinate synthase gene."xsd:string |
| http://purl.uniprot.org/citations/9446639 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/9446639 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9446639 |
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