| http://purl.uniprot.org/citations/9448006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9448006 | http://www.w3.org/2000/01/rdf-schema#comment | "PML is a nuclear protein with growth-suppressive properties originally identified in the context of the PML-retinoic acid receptor alpha (RAR alpha) fusion protein of acute promyelocytic leukemia. PML localizes within distinct nuclear structures, called nuclear bodies, which are disrupted by the expression of PML-RAR alpha. We report that PML colocalizes with the nonphosphorylated fraction of the retinoblastoma protein (pRB) within nuclear bodies and that pRB is delocalized by PML-RAR alpha expression. Both PML and PML-RAR alpha form complexes with the nonphosphorylated form of pRB in vivo, and they interact with the pocket region of pRB. The regions of PML and PML-RAR alpha involved in pRB binding differ; in fact, the B boxes and the C-terminal region of PML, the latter of which is not present in PML-RAR alpha, are essential for the formation of stable complexes with pRB. Functionally, PML abolishes activation of glucocorticoid receptor-regulated transcription by pRB, whereas PML-RAR alpha further increases it. Our results suggest that PML may be part of transcription-regulatory complexes and that the oncogenic potential of the PML-RAR alpha protein may derive from the alteration of PML-regulated transcription."xsd:string |
| http://purl.uniprot.org/citations/9448006 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.18.2.1084"xsd:string |
| http://purl.uniprot.org/citations/9448006 | http://purl.uniprot.org/core/author | "Pelicci P.G."xsd:string |
| http://purl.uniprot.org/citations/9448006 | http://purl.uniprot.org/core/author | "Szekely L."xsd:string |
| http://purl.uniprot.org/citations/9448006 | http://purl.uniprot.org/core/author | "Colombo E."xsd:string |
| http://purl.uniprot.org/citations/9448006 | http://purl.uniprot.org/core/author | "Helin K."xsd:string |
| http://purl.uniprot.org/citations/9448006 | http://purl.uniprot.org/core/author | "Fagioli M."xsd:string |
| http://purl.uniprot.org/citations/9448006 | http://purl.uniprot.org/core/author | "Stoldt S."xsd:string |
| http://purl.uniprot.org/citations/9448006 | http://purl.uniprot.org/core/author | "Alcalay M."xsd:string |
| http://purl.uniprot.org/citations/9448006 | http://purl.uniprot.org/core/author | "Grignani F."xsd:string |
| http://purl.uniprot.org/citations/9448006 | http://purl.uniprot.org/core/author | "Tomassoni L."xsd:string |
| http://purl.uniprot.org/citations/9448006 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9448006 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/9448006 | http://purl.uniprot.org/core/pages | "1084-1093"xsd:string |
| http://purl.uniprot.org/citations/9448006 | http://purl.uniprot.org/core/title | "The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein."xsd:string |
| http://purl.uniprot.org/citations/9448006 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/9448006 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9448006 |
| http://purl.uniprot.org/citations/9448006 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9448006 |
| http://purl.uniprot.org/uniprot/P29590#attribution-8419C3ABA5CD588D415B563CD624C10A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9448006 |
| http://purl.uniprot.org/uniprot/P06400#attribution-8419C3ABA5CD588D415B563CD624C10A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9448006 |