| http://purl.uniprot.org/citations/9450754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9450754 | http://www.w3.org/2000/01/rdf-schema#comment | "Point mutations in the presenilin-1 gene (PS1) are a major cause of familial Alzheimer's disease. They result in a selective increase in the production of the amyloidogenic peptide amyloid-beta(1-42) by proteolytic processing of the amyloid precursor protein (APP). Here we investigate whether PS1 is also involved in normal APP processing in neuronal cultures derived from PS1-deficient mouse embryos. Cleavage by alpha- and beta-secretase of the extracellular domain of APP was not affected by the absence of PS1, whereas cleavage by gamma-secretase of the transmembrane domain of APP was prevented, causing carboxyl-terminal fragments of APP to accumulate and a fivefold drop in the production of amyloid peptide. Pulse-chase experiments indicated that PS1 deficiency specifically decreased the turnover of the membrane-associated fragments of APP. As in the regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor, PS1 appears to facilitate a proteolytic activity that cleaves the integral membrane domain of APP. Our results indicate that mutations in PS1 that manifest clinically cause a gain of function and that inhibition of PS1 activity is a potential target for anti-amyloidogenic therapy in Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/9450754 | http://purl.org/dc/terms/identifier | "doi:10.1038/34910"xsd:string |
| http://purl.uniprot.org/citations/9450754 | http://purl.uniprot.org/core/author | "Van Leuven F."xsd:string |
| http://purl.uniprot.org/citations/9450754 | http://purl.uniprot.org/core/author | "Annaert W."xsd:string |
| http://purl.uniprot.org/citations/9450754 | http://purl.uniprot.org/core/author | "Craessaerts K."xsd:string |
| http://purl.uniprot.org/citations/9450754 | http://purl.uniprot.org/core/author | "De Strooper B."xsd:string |
| http://purl.uniprot.org/citations/9450754 | http://purl.uniprot.org/core/author | "Vanderstichele H."xsd:string |
| http://purl.uniprot.org/citations/9450754 | http://purl.uniprot.org/core/author | "Saftig P."xsd:string |
| http://purl.uniprot.org/citations/9450754 | http://purl.uniprot.org/core/author | "Guhde G."xsd:string |
| http://purl.uniprot.org/citations/9450754 | http://purl.uniprot.org/core/author | "Von Figura K."xsd:string |
| http://purl.uniprot.org/citations/9450754 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9450754 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9450754 | http://purl.uniprot.org/core/pages | "387-390"xsd:string |
| http://purl.uniprot.org/citations/9450754 | http://purl.uniprot.org/core/title | "Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein."xsd:string |
| http://purl.uniprot.org/citations/9450754 | http://purl.uniprot.org/core/volume | "391"xsd:string |
| http://purl.uniprot.org/citations/9450754 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9450754 |
| http://purl.uniprot.org/citations/9450754 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9450754 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1F2-mappedCitation-9450754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9450754 |
| http://purl.uniprot.org/uniprot/#_D3Z0X1-mappedCitation-9450754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9450754 |
| http://purl.uniprot.org/uniprot/#_Q3U4P5-mappedCitation-9450754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9450754 |
| http://purl.uniprot.org/uniprot/#_P49769-mappedCitation-9450754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9450754 |
| http://purl.uniprot.org/uniprot/#_Q3TDW2-mappedCitation-9450754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9450754 |
| http://purl.uniprot.org/uniprot/#_Q3UYK2-mappedCitation-9450754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9450754 |
| http://purl.uniprot.org/uniprot/#_Q61144-mappedCitation-9450754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9450754 |