| http://purl.uniprot.org/citations/9452421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9452421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9452421 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin receptor (IR) and the related insulin-like growth factor-I (IGF-I) receptor (IGF-IR) mediate a variety of metabolic and mitogenic cellular responses, some of which may involve unidentified receptor targets. A Src homology-2 (SH2) domain-coding region of a mouse protein was cloned based on its interaction with IR. It was designated mSH2-B based on its high similarity to an earlier reported rat sequence SH2-B. A role of mSH2-B in IGF-I and insulin action was suggested by the interaction of the SH2 domain with activated IGF-IR and IR catalytic fragments but not with an inactive IR catalytic fragment in the yeast two-hybrid system in vivo and by the hormone-dependent association of a glutathione S-transferase (GST) SH2 domain fusion protein of mSH2-B with both receptors in cell extracts. A comparison of IGF-IR and IR mutants lacking individual Tyr autophosphorylation sites for association with GST mSH2-B showed that homologous juxtamembrane (IR960/IGF-IR950) and C-terminal (IR1322/IGF-IR1316) receptor motifs were required. Synthetic phosphopeptides representing IR960 and IR1322 competed for GST mSH2-B binding to the receptor, suggesting that both motifs participate in the association with mSH2-B. Antibodies raised against GST mSH2-B identified a cellular protein of 92 kDa that was not found to be phosphorylated on Tyr. It co-immunoprecipitated with IGF-IR or IR, which was strictly dependent on receptor activation. IR and IGF-IR Tyr phosphorylation motifs were not identified in the complete SH2-B primary structure, suggesting that it may participate as an adapter rather than a substrate in the IGF-I and insulin signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/9452421 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.6.3136"xsd:string |
| http://purl.uniprot.org/citations/9452421 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.6.3136"xsd:string |
| http://purl.uniprot.org/citations/9452421 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/9452421 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/9452421 | http://purl.uniprot.org/core/author | "Riedel H."xsd:string |
| http://purl.uniprot.org/citations/9452421 | http://purl.uniprot.org/core/author | "Riedel H."xsd:string |
| http://purl.uniprot.org/citations/9452421 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9452421 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9452421 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9452421 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9452421 | http://purl.uniprot.org/core/pages | "3136-3139"xsd:string |
| http://purl.uniprot.org/citations/9452421 | http://purl.uniprot.org/core/pages | "3136-3139"xsd:string |
| http://purl.uniprot.org/citations/9452421 | http://purl.uniprot.org/core/title | "Insulin-like growth factor-I receptor and insulin receptor association with a Src homology-2 domain-containing putative adapter."xsd:string |
| http://purl.uniprot.org/citations/9452421 | http://purl.uniprot.org/core/title | "Insulin-like growth factor-I receptor and insulin receptor association with a Src homology-2 domain-containing putative adapter."xsd:string |
| http://purl.uniprot.org/citations/9452421 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/9452421 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/9452421 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9452421 |
| http://purl.uniprot.org/citations/9452421 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9452421 |
| http://purl.uniprot.org/citations/9452421 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9452421 |
| http://purl.uniprot.org/citations/9452421 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9452421 |
| http://purl.uniprot.org/uniprot/Q91ZM2 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9452421 |
| http://purl.uniprot.org/uniprot/#_Q91ZM2-citation-9452421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9452421 |