| http://purl.uniprot.org/citations/9475748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9475748 | http://www.w3.org/2000/01/rdf-schema#comment | "Although the recessive murine mutation misty (m) is well known, its phenotype has never been reported beyond brief descriptions of a dilution of coat color and white spotting of the belly and extremities, suggesting a developmental mutation. A report in abstract has also suggested effects on white fat and body weight. Here, we report effects of the homozygous misty mutation on an unusual combination of three cell types: melanocytes, platelets, and brown fat. Brown fat appeared to be completely absent from all expected locations in neonatal m/m mice. A prolonged bleeding time was observed; platelet count and platelet serotonin and ATP levels were normal, but the level of ADP in m/m platelets was low. Primary cultures and immortal lines of melanocytes from m/m mice showed several abnormalities. There was a marked deficiency in net proliferation, suggesting that the color dilution and spotting in vivo may result from reduced numbers of melanocytes and their precursors. m/m melanocytes were also hyperdendritic in morphology, overproduced melanin, and had deficient responses to the cAMP agonists cholera toxin and melanocyte-stimulating hormone, which normally promote melanin production. The misty gene product may be involved in adenine nucleotide metabolism or signaling."xsd:string |
| http://purl.uniprot.org/citations/9475748 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/148.1.381"xsd:string |
| http://purl.uniprot.org/citations/9475748 | http://purl.uniprot.org/core/author | "Bennett D.C."xsd:string |
| http://purl.uniprot.org/citations/9475748 | http://purl.uniprot.org/core/author | "Novak E.K."xsd:string |
| http://purl.uniprot.org/citations/9475748 | http://purl.uniprot.org/core/author | "Swank R.T."xsd:string |
| http://purl.uniprot.org/citations/9475748 | http://purl.uniprot.org/core/author | "Sviderskaya E.V."xsd:string |
| http://purl.uniprot.org/citations/9475748 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9475748 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/9475748 | http://purl.uniprot.org/core/pages | "381-390"xsd:string |
| http://purl.uniprot.org/citations/9475748 | http://purl.uniprot.org/core/title | "The murine misty mutation: phenotypic effects on melanocytes, platelets and brown fat."xsd:string |
| http://purl.uniprot.org/citations/9475748 | http://purl.uniprot.org/core/volume | "148"xsd:string |
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