| http://purl.uniprot.org/citations/9486797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9486797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9486797 | http://www.w3.org/2000/01/rdf-schema#comment | "In Xenopus, cdc2 tyrosine phosphorylation is detected in the first 60-75 minute cell cycle but not in the next eleven cell cycles (cycles 2-12) which are only 30 minutes long. Here we report that the wee1/cdc25 ratio increases before the first mitotic interphase. We show that the Xe-wee1 protein is absent in stage VI oocytes and is expressed from meiosis II until gastrulation. A dominant negative form of Xe-wee1 (KM wee1) reduced the level cdc2 tyrosine phosphorylation and length of the first cycle. However, the ratio of wee1/cdc25 did not decrease after the first cycle and therefore did not explain the lack of cdc2 tyrosine phosphorylation in, nor the rapidity of, cycles 2-12. Furthermore, there was no evidence for a wee1/myt1 inhibitor in cycles 2-12. We examined the role of Mos in the first cycle because it is present during the first 20 minutes of this cycle. We arrested the rapid embryonic cell cycle (cycle 2 or 3) with Mos and restarted the cell cycle with calcium ionophore; the 30 minute cycle was converted into a 60 minute cycle, with cdc2 tyrosine phosphorylation. In addition, the injection of a non-degradable Mos (MBP-Mos) into the first cycle resulted in a dramatic elongation of this cycle (to 140 minutes). MBP-Mos did not delay DNA replication or the translation of cyclins A or B; it did, however, result in the marked accumulation of tyrosine phosphorylated cdc2. Thus, while the wee1/cdc25 ratio changes during development, these changes may not be responsible for the variety of cell cycles observed during early Xenopus embryogenesis. Our experiments indicate that Mos/MAPK can also contribute to cell cycle length."xsd:string |
| http://purl.uniprot.org/citations/9486797 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.125.2.237"xsd:string |
| http://purl.uniprot.org/citations/9486797 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.125.2.237"xsd:string |
| http://purl.uniprot.org/citations/9486797 | http://purl.uniprot.org/core/author | "Vande Woude G.F."xsd:string |
| http://purl.uniprot.org/citations/9486797 | http://purl.uniprot.org/core/author | "Vande Woude G.F."xsd:string |
| http://purl.uniprot.org/citations/9486797 | http://purl.uniprot.org/core/author | "Murakami M.S."xsd:string |
| http://purl.uniprot.org/citations/9486797 | http://purl.uniprot.org/core/author | "Murakami M.S."xsd:string |
| http://purl.uniprot.org/citations/9486797 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9486797 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9486797 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/9486797 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/9486797 | http://purl.uniprot.org/core/pages | "237-248"xsd:string |
| http://purl.uniprot.org/citations/9486797 | http://purl.uniprot.org/core/pages | "237-248"xsd:string |
| http://purl.uniprot.org/citations/9486797 | http://purl.uniprot.org/core/title | "Analysis of the early embryonic cell cycles of Xenopus; regulation of cell cycle length by Xe-wee1 and Mos."xsd:string |
| http://purl.uniprot.org/citations/9486797 | http://purl.uniprot.org/core/title | "Analysis of the early embryonic cell cycles of Xenopus; regulation of cell cycle length by Xe-wee1 and Mos."xsd:string |
| http://purl.uniprot.org/citations/9486797 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/9486797 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/9486797 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9486797 |
| http://purl.uniprot.org/citations/9486797 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9486797 |
| http://purl.uniprot.org/citations/9486797 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9486797 |
| http://purl.uniprot.org/citations/9486797 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9486797 |
| http://purl.uniprot.org/uniprot/P24033 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9486797 |
| http://purl.uniprot.org/uniprot/P35567 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9486797 |