| http://purl.uniprot.org/citations/9488492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9488492 | http://www.w3.org/2000/01/rdf-schema#comment | "The yeast protein Rbl2p suppresses the deleterious effects of excess beta-tubulin as efficiently as does alpha-tubulin. Both in vivo and in vitro, Rbl2p forms a complex with beta-tubulin that does not contain alpha-tubulin, thus defining a second pool of beta-tubulin in the cell. Formation of the complex depends upon the conformation of beta-tubulin. Newly synthesized beta-tubulin can bind to Rbl2p before it binds to alpha-tubulin. Rbl2p can also bind beta-tubulin from the alpha/beta-tubulin heterodimer, apparently by competing with alpha-tubulin. The Rbl2p-beta-tubulin complex has a half-life of approximately 2.5 h and is less stable than the alpha/beta-tubulin heterodimer. The results of our experiments explain both how excess Rbl2p can rescue cells overexpressing beta-tubulin and how it can be deleterious in a wild-type background. They also suggest that the Rbl2p-beta-tubulin complex is part of a cellular mechanism for regulating the levels and dimerization of tubulin chains."xsd:string |
| http://purl.uniprot.org/citations/9488492 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.18.3.1757"xsd:string |
| http://purl.uniprot.org/citations/9488492 | http://purl.uniprot.org/core/author | "Solomon F."xsd:string |
| http://purl.uniprot.org/citations/9488492 | http://purl.uniprot.org/core/author | "Magendantz M."xsd:string |
| http://purl.uniprot.org/citations/9488492 | http://purl.uniprot.org/core/author | "Vega L.R."xsd:string |
| http://purl.uniprot.org/citations/9488492 | http://purl.uniprot.org/core/author | "Archer J.E."xsd:string |
| http://purl.uniprot.org/citations/9488492 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9488492 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/9488492 | http://purl.uniprot.org/core/pages | "1757-1762"xsd:string |
| http://purl.uniprot.org/citations/9488492 | http://purl.uniprot.org/core/title | "Formation and function of the Rbl2p-beta-tubulin complex."xsd:string |
| http://purl.uniprot.org/citations/9488492 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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