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| http://purl.uniprot.org/citations/9489697 | http://www.w3.org/2000/01/rdf-schema#comment | "To investigate the role of phosphatases in synaptic plasticity using genetic approaches, we generated transgenic mice that overexpress a truncated form of calcineurin under the control of the CaMKIIalpha promoter. Mice expressing this transgene show increased calcium-dependent phosphatase activity in the hippocampus. Physiological studies of these mice and parallel pharmacological experiments in wild-type mice reveal a novel, intermediate phase of LTP (I-LTP) in the CA1 region of the hippocampus. This intermediate phase differs from E-LTP by requiring multiple trains for induction and in being dependent on PKA. It differs from L-LTP in not requiring new protein synthesis. These data suggest that calcineurin acts as an inhibitory constraint on I-LTP that is relieved by PKA. This inhibitory constraint acts as a gate to regulate the synaptic induction of L-LTP."xsd:string |
| http://purl.uniprot.org/citations/9489697 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80896-x"xsd:string |
| http://purl.uniprot.org/citations/9489697 | http://purl.uniprot.org/core/author | "Kandel E.R."xsd:string |
| http://purl.uniprot.org/citations/9489697 | http://purl.uniprot.org/core/author | "Mansuy I.M."xsd:string |
| http://purl.uniprot.org/citations/9489697 | http://purl.uniprot.org/core/author | "Osman M."xsd:string |
| http://purl.uniprot.org/citations/9489697 | http://purl.uniprot.org/core/author | "Winder D.G."xsd:string |
| http://purl.uniprot.org/citations/9489697 | http://purl.uniprot.org/core/author | "Moallem T.M."xsd:string |
| http://purl.uniprot.org/citations/9489697 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9489697 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9489697 | http://purl.uniprot.org/core/pages | "25-37"xsd:string |
| http://purl.uniprot.org/citations/9489697 | http://purl.uniprot.org/core/title | "Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin."xsd:string |
| http://purl.uniprot.org/citations/9489697 | http://purl.uniprot.org/core/volume | "92"xsd:string |
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