| http://purl.uniprot.org/citations/9491887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9491887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9491887 | http://www.w3.org/2000/01/rdf-schema#comment | "The HIV-1 Tat protein regulates transcription elongation through binding to the viral TAR RNA stem-loop structure. We have isolated a novel 87 kDa cyclin C-related protein (cyclin T) that interacts specifically with the transactivation domain of Tat. Cyclin T is a partner for CDK9, an RNAPII transcription elongation factor. Remarkably, the interaction of Tat with cyclin T strongly enhances the affinity and specificity of the Tat:TAR RNA interaction, and confers a requirement for sequences in the loop of TAR that are not recognized by Tat alone. Moreover, overexpression of human cyclin T rescues Tat activity in nonpermissive rodent cells. We propose that Tat directs cyclin T-CDK9 to RNAPII through cooperative binding to TAR RNA."xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80939-3"xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80939-3"xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/author | "Jones K.A."xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/author | "Jones K.A."xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/author | "Fischer W.H."xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/author | "Fischer W.H."xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/author | "Wei P."xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/author | "Wei P."xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/author | "Fang S.-M."xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/author | "Fang S.-M."xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/author | "Garber M.E."xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/author | "Garber M.E."xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/pages | "451-462"xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/pages | "451-462"xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/title | "A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA."xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/title | "A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA."xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/volume | "92"xsd:string |
| http://purl.uniprot.org/citations/9491887 | http://purl.uniprot.org/core/volume | "92"xsd:string |