| http://purl.uniprot.org/citations/9492289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9492289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9492289 | http://www.w3.org/2000/01/rdf-schema#comment | "cDNAs coding for class II alcohol dehydrogenase were isolated from a rabbit-liver cDNA library. Deduced amino acid sequences show that isozymic forms of rabbit class II alcohol dehydrogenase exist, with a positional identity of 88.4%. A high variability in structure of class II alcohol dehydrogenase between the species is also reflected in function. The rabbit II-1 isozyme shows common characteristics with the human enzyme, but has a lower Km value for ethanol, 4.2 mM. The II-2 isozyme shows restriction for aliphatic alcohols longer than pentanol. For shorter alcohols the II-2 form has similar Km values as the II-1 isozyme, 5.5 mM for ethanol, but is a low activity variant with a 10-fold decrease in k(cat) values compared with II-1. Nevertheless, II-2 has a higher specificity for benzoquinone than II-1 due to a lower Km value, 80 microM compared with 1 mM, and is in this sense more like the human class II enzyme. In addition a rabbit class III alcohol dehydrogenase cDNA was isolated that encodes a typical class III enzyme/glutathione-dependent formaldehyde dehydrogenase. The finding of isozymic forms of class II alcohol dehydrogenase is in line with the evolution of the system of medium-chain alcohol dehydrogenases with different enzymes, different classes and different isozymes and further underline the complexity of the entire mammalian alcohol dehydrogenase system."xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1432-1327.1998.2510236.x"xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1432-1327.1998.2510236.x"xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://purl.uniprot.org/core/author | "Hoeoeg J.-O."xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://purl.uniprot.org/core/author | "Hoeoeg J.-O."xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://purl.uniprot.org/core/author | "Svensson S."xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://purl.uniprot.org/core/author | "Svensson S."xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://purl.uniprot.org/core/author | "Hedberg J."xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://purl.uniprot.org/core/author | "Hedberg J."xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9492289 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9492289 | http://purl.uniprot.org/core/name | "Eur. J. Biochem."xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://purl.uniprot.org/core/name | "Eur. J. Biochem."xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://purl.uniprot.org/core/pages | "236-243"xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://purl.uniprot.org/core/pages | "236-243"xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://purl.uniprot.org/core/title | "Structural and functional divergence of class II alcohol dehydrogenase -- cloning and characterisation of rabbit liver isoforms of the enzyme."xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://purl.uniprot.org/core/title | "Structural and functional divergence of class II alcohol dehydrogenase -- cloning and characterisation of rabbit liver isoforms of the enzyme."xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://purl.uniprot.org/core/volume | "251"xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://purl.uniprot.org/core/volume | "251"xsd:string |
| http://purl.uniprot.org/citations/9492289 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9492289 |
| http://purl.uniprot.org/citations/9492289 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9492289 |
| http://purl.uniprot.org/citations/9492289 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9492289 |
| http://purl.uniprot.org/citations/9492289 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9492289 |