| http://purl.uniprot.org/citations/9494094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9494094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9494094 | http://www.w3.org/2000/01/rdf-schema#comment | "A new splice variant of the human integrin subunit beta1 has been identified and designated beta1C-2. It differs from the previously reported beta1C (in this report designated beta1C-1) by 18 nucleotides, and is generated by splicing from exon 6 to an alternative splice acceptor site within exon C, causing an in-frame deletion of six amino acids of the cytoplasmic region of beta1C-1. The beta1C-2 mRNA is present in several human cell lines and tissues at low levels, similarly to beta1C-1. In peripheral T-lymphocytes, beta1C-2 is the selectively expressed isoform. Neither beta1C-1 nor beta1C-2 mRNA could be detected in mouse tissues, and Southern hybridization of a mouse genomic beta1 clone with a human exon-C-specific probe failed to identify a corresponding mouse exon. The antisense orientation of exon C is highly homologous to an Alu element. Since Alu elements are restricted to primates, the beta1C-1 and beta1C-2 variants of the integrin subunit beta1 are specific for these species. The protein coded for by the beta1C-2 cDNA can be expressed and localized to the surface of beta1 deficient mouse cells. However, while stable transformed clones expressing high levels of the beta1A were commonly found, the beta1C-1 and beta1C-2 expressing clones expressed barely detectable amounts of the beta1 protein. Hence, high levels of beta1C-2 may be incompatible with cell proliferation, as previously suggested for beta1C-1."xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj3301255"xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj3301255"xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://purl.uniprot.org/core/author | "Johansson S."xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://purl.uniprot.org/core/author | "Johansson S."xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://purl.uniprot.org/core/author | "Faessler R."xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://purl.uniprot.org/core/author | "Faessler R."xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://purl.uniprot.org/core/author | "Svineng G."xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://purl.uniprot.org/core/author | "Svineng G."xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9494094 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9494094 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://purl.uniprot.org/core/pages | "1255-1263"xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://purl.uniprot.org/core/pages | "1255-1263"xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://purl.uniprot.org/core/title | "Identification of beta1C-2, a novel variant of the integrin beta1 subunit generated by utilization of an alternative splice acceptor site in exon C."xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://purl.uniprot.org/core/title | "Identification of beta1C-2, a novel variant of the integrin beta1 subunit generated by utilization of an alternative splice acceptor site in exon C."xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://purl.uniprot.org/core/volume | "330"xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://purl.uniprot.org/core/volume | "330"xsd:string |
| http://purl.uniprot.org/citations/9494094 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9494094 |
| http://purl.uniprot.org/citations/9494094 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9494094 |
| http://purl.uniprot.org/citations/9494094 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9494094 |
| http://purl.uniprot.org/citations/9494094 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9494094 |