| http://purl.uniprot.org/citations/9497363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9497363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9497363 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of the trabecular meshwork inducible glucocorticoid response (TIGR) gene progressively increases from barely detectable levels to greater than 2% of total cellular mRNA over 10 days exposure of trabecular meshwork (TM) cells to dexamethasone. Cycloheximide blocked most of the TIGR mRNA induction, suggesting a requirement for ongoing protein synthesis. The genomic structure of TIGR (approximately 20 kilobases) consists of 3 exons, and a 5-kilobase promoter region that contains 13 predicted hormone response elements, including several glucocorticoid regulatory elements, and other potentially important regulatory motifs. TIGR cDNA encodes an olfactomedin-related glycoprotein of 504 amino acids with motifs for N- and O-linked glycosylation, glycosaminoglycan initiation, hyaluronic acid binding, and leucine zippers. Recombinant TIGR (rTIGR) showed oligomerization and specific binding to TM cells. Anti-rTIGR antibody detected multiple translational/post-translational forms of TIGR produced by the cells (including secreted 66 kDa/55 kDa glycoproteins/proteins in the media and 55 kDa cellular proteins), whereas Northern blot showed a single mRNA species. The findings suggest potential mechanisms by which TIGR could obstruct the aqueous humor fluid flow and participate in the pathogenesis of glaucoma."xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.11.6341"xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.11.6341"xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/author | "Chen P."xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/author | "Chen P."xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/author | "Johnson D."xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/author | "Johnson D."xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/author | "Huang W.D."xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/author | "Huang W.D."xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/author | "Nguyen T.D."xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/author | "Nguyen T.D."xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/author | "Polansky J.R."xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/author | "Polansky J.R."xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/pages | "6341-6350"xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/pages | "6341-6350"xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/title | "Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells."xsd:string |
| http://purl.uniprot.org/citations/9497363 | http://purl.uniprot.org/core/title | "Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells."xsd:string |