| http://purl.uniprot.org/citations/9501083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9501083 | http://www.w3.org/2000/01/rdf-schema#comment | "The sarcomeric Z-disk, the anchoring plane of thin (actin) filaments, links titin (also called connectin) and actin filaments from opposing sarcomere halves in a lattice connected by alpha-actinin. We demonstrate by protein interaction analysis that two types of titin interactions are involved in the assembly of alpha-actinin into the Z-disk. Titin interacts via a single binding site with the two central spectrin-like repeats of the outermost pair of alpha-actinin molecules. In the central Z-disk, titin can interact with multiple alpha-actinin molecules via their C-terminal domains. These interactions allow the assembly of a ternary complex of titin, actin and alpha-actinin in vitro, and are expected to constrain the path of titin in the Z-disk. In thick skeletal muscle Z-disks, titin filaments cross over the Z-disk centre by approximately 30 nm, suggesting that their alpha-actinin-binding sites overlap in an antiparallel fashion. The combination of our biochemical and ultrastructural data now allows a molecular model of the sarcomeric Z-disk, where overlapping titin filaments and their interactions with the alpha-actinin rod and C-terminal domain can account for the essential ultrastructural features."xsd:string |
| http://purl.uniprot.org/citations/9501083 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/17.6.1614"xsd:string |
| http://purl.uniprot.org/citations/9501083 | http://purl.uniprot.org/core/author | "Gautel M."xsd:string |
| http://purl.uniprot.org/citations/9501083 | http://purl.uniprot.org/core/author | "Young P."xsd:string |
| http://purl.uniprot.org/citations/9501083 | http://purl.uniprot.org/core/author | "Ferguson C."xsd:string |
| http://purl.uniprot.org/citations/9501083 | http://purl.uniprot.org/core/author | "Banuelos S."xsd:string |
| http://purl.uniprot.org/citations/9501083 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9501083 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/9501083 | http://purl.uniprot.org/core/pages | "1614-1624"xsd:string |
| http://purl.uniprot.org/citations/9501083 | http://purl.uniprot.org/core/title | "Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin."xsd:string |
| http://purl.uniprot.org/citations/9501083 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/9501083 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9501083 |
| http://purl.uniprot.org/citations/9501083 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9501083 |
| http://purl.uniprot.org/uniprot/P35609#attribution-73DC2B564E12EAB726CC1963A45D3BDB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9501083 |
| http://purl.uniprot.org/uniprot/P20929#attribution-2B415D7AEFE8BF5CA64ECDCD35871B76 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9501083 |
| http://purl.uniprot.org/uniprot/Q8WZ42#attribution-73DC2B564E12EAB726CC1963A45D3BDB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9501083 |
| http://purl.uniprot.org/uniprot/Q8WZ42#attribution-F5453D79514FAF6F55BEEFD9CCFF5F31 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9501083 |
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| http://purl.uniprot.org/uniprot/#_P62736-mappedCitation-9501083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9501083 |
| http://purl.uniprot.org/uniprot/#_Q8WZ42-mappedCitation-9501083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9501083 |
| http://purl.uniprot.org/uniprot/P35609 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9501083 |
| http://purl.uniprot.org/uniprot/Q8WZ42 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9501083 |
| http://purl.uniprot.org/uniprot/P62736 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9501083 |