http://purl.uniprot.org/citations/9501216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/9501216 | http://www.w3.org/2000/01/rdf-schema#comment | "How memory T cells are maintained in vivo is poorly understood. To address this problem, a male-specific peptide (H-Y) was identified and used to activate female anti-H-Y T cells in vitro. Anti-H-Y T cells survived in vivo for at least 70 days in the absence of antigen. This persistence was not because of the intrinsic ability of memory T cells to survive in vivo. Instead, the survival and function of adoptively transferred memory cells was found to require transporter of antigen protein 1-dependent expression of self-peptide/major histocompatibility complex class I molecules in recipient animals. Therefore, it appears that the level of T cell receptor engagement provided by transporter of antigen protein 1-dependent, self-peptide/major histocompatibility complexes is sufficient to maintain the long-term survival and functional phenotype of memory cells in the absence of persistent antigen. These data suggest that positive selection plays a role not only in T cell development but also in the maintenance of T cell memory."xsd:string |
http://purl.uniprot.org/citations/9501216 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.6.3065"xsd:string |
http://purl.uniprot.org/citations/9501216 | http://purl.uniprot.org/core/author | "Hu Q."xsd:string |
http://purl.uniprot.org/citations/9501216 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
http://purl.uniprot.org/citations/9501216 | http://purl.uniprot.org/core/author | "Thompson C.B."xsd:string |
http://purl.uniprot.org/citations/9501216 | http://purl.uniprot.org/core/author | "Ashton-Rickardt P.G."xsd:string |
http://purl.uniprot.org/citations/9501216 | http://purl.uniprot.org/core/author | "Bishop C.E."xsd:string |
http://purl.uniprot.org/citations/9501216 | http://purl.uniprot.org/core/author | "Opferman J.T."xsd:string |
http://purl.uniprot.org/citations/9501216 | http://purl.uniprot.org/core/author | "Agulnik A.A."xsd:string |
http://purl.uniprot.org/citations/9501216 | http://purl.uniprot.org/core/author | "Girao C."xsd:string |
http://purl.uniprot.org/citations/9501216 | http://purl.uniprot.org/core/author | "Markiewicz M.A."xsd:string |
http://purl.uniprot.org/citations/9501216 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
http://purl.uniprot.org/citations/9501216 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
http://purl.uniprot.org/citations/9501216 | http://purl.uniprot.org/core/pages | "3065-3070"xsd:string |
http://purl.uniprot.org/citations/9501216 | http://purl.uniprot.org/core/title | "Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules."xsd:string |
http://purl.uniprot.org/citations/9501216 | http://purl.uniprot.org/core/volume | "95"xsd:string |
http://purl.uniprot.org/citations/9501216 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9501216 |
http://purl.uniprot.org/citations/9501216 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9501216 |
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http://purl.uniprot.org/uniprot/#_Q62428-mappedCitation-9501216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9501216 |