| http://purl.uniprot.org/citations/9507149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9507149 | http://www.w3.org/2000/01/rdf-schema#comment | "We isolated genes for the opioid receptor homologue MOR-C, namely nociceptin receptor (designated alternatively as orphanin FQ receptor) and generated nociceptin receptor-knockout mice. Previously, we have reported that the nociceptin system appears to participate in the regulation of the auditory system. However, the behavior of the nociceptin receptor-knockout mice has yet to be fully characterized. In the present study, we investigated changes in several behavioral performances in mice which lack nociceptin receptor. Nociceptive thresholds of nociceptin receptor-knockout mice were unchanged in the hot-plate and electric foot-shock tests as well as tail-flick and acetic-acid-induced writhing tests compared to those of wild-type mice. The nociceptin receptor-knockout mice did not show any behavioral changes in the elevated plus-maze task. Surprisingly, in the water-finding test, the nociceptin receptor-knockout mice showed an enhanced retention of spatial attention (latent learning) compared to wild-type mice. In a biochemical study, dopamine content in the frontal cortex was lower in nociceptin receptor-knockout mice than wild-type mice. These results suggest that nociceptin receptor plays an important role in spatial attention by regulating the dopaminergic system in the brain."xsd:string |
| http://purl.uniprot.org/citations/9507149 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-8993(97)01406-6"xsd:string |
| http://purl.uniprot.org/citations/9507149 | http://purl.uniprot.org/core/author | "Takeshima H."xsd:string |
| http://purl.uniprot.org/citations/9507149 | http://purl.uniprot.org/core/author | "Noda Y."xsd:string |
| http://purl.uniprot.org/citations/9507149 | http://purl.uniprot.org/core/author | "Nishi M."xsd:string |
| http://purl.uniprot.org/citations/9507149 | http://purl.uniprot.org/core/author | "Mamiya T."xsd:string |
| http://purl.uniprot.org/citations/9507149 | http://purl.uniprot.org/core/author | "Nabeshima T."xsd:string |
| http://purl.uniprot.org/citations/9507149 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9507149 | http://purl.uniprot.org/core/name | "Brain Res"xsd:string |
| http://purl.uniprot.org/citations/9507149 | http://purl.uniprot.org/core/pages | "236-240"xsd:string |
| http://purl.uniprot.org/citations/9507149 | http://purl.uniprot.org/core/title | "Enhancement of spatial attention in nociceptin/orphanin FQ receptor-knockout mice."xsd:string |
| http://purl.uniprot.org/citations/9507149 | http://purl.uniprot.org/core/volume | "783"xsd:string |
| http://purl.uniprot.org/citations/9507149 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9507149 |
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