| http://purl.uniprot.org/citations/9516414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9516414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9516414 | http://www.w3.org/2000/01/rdf-schema#comment | "Chemokines are key players in inflammation and infection. Natural forms of the C-X-C chemokine granulocyte chemotactic protein-2 (GCP-2) and the C-C chemokine regulated on activation normal T cell expressed and secreted (RANTES), which miss two NH2-terminal residues, including a Pro in the penultimate position, have been isolated from leukocytes or tumor cells. In chemotaxis and intracellular calcium mobilization assays, the truncation caused a reduction in the specific activity of RANTES but not of GCP-2. The serine protease CD26/dipeptidyl-peptidase IV (CD26/DPP IV) could induce this observed NH2-terminal truncation of GCP-2 and RANTES but not that of the monocyte chemotactic proteins MCP-1, MCP-2 and MCP-3. No significant difference in neutrophil activation was detected between intact and CD26/DPP IV-truncated GCP-2. In contrast to intact natural RANTES(1-68), which still chemoattracts monocytes at 10 ng/ml, CD26/DPP IV-truncated RANTES(3-68) was inactive at 300 ng/ml and behaved as a natural chemotaxis inhibitor. Compared with intact RANTES, only a 10-fold higher concentration of RANTES(3-68) induced a significant Ca2+ response. Furthermore, RANTES(3-68) inhibited infection of mononuclear cells by an M-tropic HIV-1 strain 5-fold more efficiently than intact RANTES. Thus, proteolytic processing of RANTES by CD26/DPP IV may constitute an important regulatory mechanism during anti-inflammatory and antiviral responses."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.13.7222"xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.13.7222"xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "Van Damme J."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "Van Damme J."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "Lambeir A.-M."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "Lambeir A.-M."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "Proost P."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "Proost P."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "De Meester I."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "De Meester I."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "Scharpe S."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "Scharpe S."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "De Clercq E."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "De Clercq E."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "Opdenakker G."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "Opdenakker G."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "Struyf S."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "Struyf S."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "Wuyts A."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "Wuyts A."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "Schols D."xsd:string |
| http://purl.uniprot.org/citations/9516414 | http://purl.uniprot.org/core/author | "Schols D."xsd:string |