| http://purl.uniprot.org/citations/9519731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9519731 | http://www.w3.org/2000/01/rdf-schema#comment | "Reduction in the activity of the alpha-melanocyte-stimulating hormone (alpha-MSH) system causes obesity, and infusions of alpha-MSH can produce satiety, raising the possibility that alpha-MSH may mediate physiological satiety signals. Since alpha-MSH is coded for by the pro-opiomelanocortin (POMC) gene, we examined if POMC gene expression would be inhibited by fasting in normal mice or in models of obesity characterized by leptin insufficiency (ob/ob) or leptin insensitivity (db/db). In wild-type mice, hypothalamic POMC mRNA was decreased > 60% after a 2-day fast and was positively correlated with leptin mRNA. Similarly, compared with controls, POMC mRNA was decreased by at least 60% in both db/db and ob/ob mice. POMC mRNA was negatively correlated with both neuropeptide Y (NPY) and melanin-concentrating hormone (MCH) mRNA. Finally, treatment of both male and female ob/ob mice with leptin stimulated hypothalamic POMC mRNA by about threefold. These results suggest that impairment in production, processing, or responsiveness to alpha-MSH may be a common feature of obesity and that hypothalamic POMC neurons, stimulated by leptin, may constitute a link between leptin and the melanocortin system."xsd:string |
| http://purl.uniprot.org/citations/9519731 | http://purl.org/dc/terms/identifier | "doi:10.2337/diab.47.2.294"xsd:string |
| http://purl.uniprot.org/citations/9519731 | http://purl.uniprot.org/core/author | "Roberts J.L."xsd:string |
| http://purl.uniprot.org/citations/9519731 | http://purl.uniprot.org/core/author | "Mobbs C.V."xsd:string |
| http://purl.uniprot.org/citations/9519731 | http://purl.uniprot.org/core/author | "Kleopoulos S.P."xsd:string |
| http://purl.uniprot.org/citations/9519731 | http://purl.uniprot.org/core/author | "Mizuno T.M."xsd:string |
| http://purl.uniprot.org/citations/9519731 | http://purl.uniprot.org/core/author | "Bergen H.T."xsd:string |
| http://purl.uniprot.org/citations/9519731 | http://purl.uniprot.org/core/author | "Priest C.A."xsd:string |
| http://purl.uniprot.org/citations/9519731 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9519731 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/9519731 | http://purl.uniprot.org/core/pages | "294-297"xsd:string |
| http://purl.uniprot.org/citations/9519731 | http://purl.uniprot.org/core/title | "Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and in ob/ob and db/db mice, but is stimulated by leptin."xsd:string |
| http://purl.uniprot.org/citations/9519731 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/9519731 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9519731 |
| http://purl.uniprot.org/citations/9519731 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9519731 |
| http://purl.uniprot.org/uniprot/#_D0FZQ3-mappedCitation-9519731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9519731 |
| http://purl.uniprot.org/uniprot/#_A0A1C9CJK6-mappedCitation-9519731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9519731 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P7R2-mappedCitation-9519731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9519731 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P724-mappedCitation-9519731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9519731 |
| http://purl.uniprot.org/uniprot/#_A2AV66-mappedCitation-9519731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9519731 |
| http://purl.uniprot.org/uniprot/#_E9Q7Z0-mappedCitation-9519731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9519731 |
| http://purl.uniprot.org/uniprot/#_E9M0G2-mappedCitation-9519731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9519731 |
| http://purl.uniprot.org/uniprot/#_P41160-mappedCitation-9519731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9519731 |
| http://purl.uniprot.org/uniprot/#_P48356-mappedCitation-9519731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9519731 |