| http://purl.uniprot.org/citations/9529250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9529250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9529250 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular endothelial growth factor (VEGF), a major regulator of angiogenesis, binds to two receptor tyrosine kinases, KDR/Flk-1 and Flt-1. We now describe the purification and the expression cloning from tumor cells of a third VEGF receptor, one that binds VEGF165 but not VEGF121. This isoform-specific VEGF receptor (VEGF165R) is identical to human neuropilin-1, a receptor for the collapsin/semaphorin family that mediates neuronal cell guidance. When coexpressed in cells with KDR, neuropilin-1 enhances the binding of VEGF165 to KDR and VEGF165-mediated chemotaxis. Conversely, inhibition of VEGF165 binding to neuropilin-1 inhibits its binding to KDR and its mitogenic activity for endothelial cells. We propose that neuropilin-1 is a novel VEGF receptor that modulates VEGF binding to KDR and subsequent bioactivity and therefore may regulate VEGF-induced angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81402-6"xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81402-6"xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/author | "Takashima S."xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/author | "Takashima S."xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/author | "Klagsbrun M."xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/author | "Klagsbrun M."xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/author | "Neufeld G."xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/author | "Neufeld G."xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/author | "Miao H.-Q."xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/author | "Miao H.-Q."xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/author | "Soker S."xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/author | "Soker S."xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/pages | "735-745"xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/pages | "735-745"xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/title | "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor."xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/title | "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor."xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/volume | "92"xsd:string |
| http://purl.uniprot.org/citations/9529250 | http://purl.uniprot.org/core/volume | "92"xsd:string |