http://purl.uniprot.org/citations/9537422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/9537422 | http://www.w3.org/2000/01/rdf-schema#comment | "Familial combined hyperlipidaemia (FCHL) is a common, multifactorial disorder associated with elevated levels of plasma triglyceride, cholesterol, or both. A characteristic feature is increased secretion of very low density lipoproteins (VLDL) and apolipoprotein B (apoB). Although FCHL is the most common cause of premature coronary artery disease (CAD), accounting for over 10% of cases, its aetiology remains largely unknown. One powerful approach to the dissection of complex genetic traits involves the use of animal models. We have identified a mouse strain, HcB-19/Dem (HcB-19), which exhibits hypertriglyceridaemia, hypercholesterolaemia and elevated levels of plasma apoB. Like FCHL patients, HcB-19 mice also exhibit increased secretion of triglyceride-rich lipoproteins, and their hyperlipidaemia becomes progressively more severe with age. It is likely that the hyperlipidaemia results from a mutation of a novel gene that arose during development of strain HcB-19. We mapped the hyperlipidaemia gene (Hyplip1) to the distal portion of mouse chromosome 3. This region is syntenic to human chromosome 1q21-q23, which has recently been shown to harbour a gene associated with FCHL in families from a Finnish isolate."xsd:string |
http://purl.uniprot.org/citations/9537422 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng0498-374"xsd:string |
http://purl.uniprot.org/citations/9537422 | http://purl.uniprot.org/core/author | "Lusis A.J."xsd:string |
http://purl.uniprot.org/citations/9537422 | http://purl.uniprot.org/core/author | "Castellani L.W."xsd:string |
http://purl.uniprot.org/citations/9537422 | http://purl.uniprot.org/core/author | "Mehrabian M."xsd:string |
http://purl.uniprot.org/citations/9537422 | http://purl.uniprot.org/core/author | "Demant P."xsd:string |
http://purl.uniprot.org/citations/9537422 | http://purl.uniprot.org/core/author | "Bodnar J."xsd:string |
http://purl.uniprot.org/citations/9537422 | http://purl.uniprot.org/core/author | "Weinreb A."xsd:string |
http://purl.uniprot.org/citations/9537422 | http://purl.uniprot.org/core/author | "Goto A.M."xsd:string |
http://purl.uniprot.org/citations/9537422 | http://purl.uniprot.org/core/author | "Doolittle M."xsd:string |
http://purl.uniprot.org/citations/9537422 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
http://purl.uniprot.org/citations/9537422 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
http://purl.uniprot.org/citations/9537422 | http://purl.uniprot.org/core/pages | "374-377"xsd:string |
http://purl.uniprot.org/citations/9537422 | http://purl.uniprot.org/core/title | "Mapping a gene for combined hyperlipidaemia in a mutant mouse strain."xsd:string |
http://purl.uniprot.org/citations/9537422 | http://purl.uniprot.org/core/volume | "18"xsd:string |
http://purl.uniprot.org/citations/9537422 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9537422 |
http://purl.uniprot.org/citations/9537422 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9537422 |
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