| http://purl.uniprot.org/citations/9546397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9546397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9546397 | http://www.w3.org/2000/01/rdf-schema#comment | "HFE is an MHC-related protein that is mutated in the iron-overload disease hereditary hemochromatosis. HFE binds to transferrin receptor (TfR) and reduces its affinity for iron-loaded transferrin, implicating HFE in iron metabolism. The 2.6 A crystal structure of HFE reveals the locations of hemochromatosis mutations and a patch of histidines that could be involved in pH-dependent interactions. We also demonstrate that soluble TfR and HFE bind tightly at the basic pH of the cell surface, but not at the acidic pH of intracellular vesicles. TfR:HFE stoichiometry (2:1) differs from TfR:transferrin stoichiometry (2:2), implying a different mode of binding for HFE and transferrin to TfR, consistent with our demonstration that HFE, transferrin, and TfR form a ternary complex."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81151-4"xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81151-4"xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/author | "Bennett M.J."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/author | "Bennett M.J."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/author | "Feder J.N."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/author | "Feder J.N."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/author | "Mintier G.A."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/author | "Mintier G.A."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/author | "Chirino A.J."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/author | "Chirino A.J."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/author | "Bjorkman P.J."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/author | "Bjorkman P.J."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/author | "Vaughn D.E."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/author | "Vaughn D.E."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/author | "Snow P.M."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/author | "Snow P.M."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/author | "Lebron J.A."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/author | "Lebron J.A."xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9546397 | http://purl.uniprot.org/core/name | "Cell"xsd:string |