| http://purl.uniprot.org/citations/9551975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9551975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9551975 | http://www.w3.org/2000/01/rdf-schema#comment | "Dimerization of MHC class II molecules on the cell surface of human THP-1 monocytic cell line is a requirement for staphylococcal superantigen (SAG)-induced cytokine gene expression. The capacities of various SAG to induce this response are governed by their modes of interaction with MHC class II molecules. Staphylococcal enterotoxin A (SEA), with its two binding sites, dimerizes MHC class II molecules and subsequently induces cytokine gene expression in THP-1 cells. Here, we demonstrate that staphylococcal enterotoxin D (SED) and staphylococcal enterotoxin E (SEE) induce, similarly, IL-1beta and TNF-alpha gene expression in these cells. Using mutated toxins that lost their binding site with the MHC class II alpha- or beta-chain, we demonstrate that this response is also mediated by the dimerization of MHC class II molecules through two binding sites. Furthermore, SED forms Zn2+-dependent homodimers that allow multiple modes of MHC class II clustering, including ligation of alpha-chains (alpha/alpha), beta-chains (beta/beta), or the alpha- and beta-chains of two different class II molecules. The beta/beta interaction following Zn2+-dependent SED/SED homodimer formation seems to be mediated by the appearance of a novel binding site on SED that interacts with histidine 81 of the MHC class II beta-chain. The different modes of SED interactions also influence SED-induced T cell activation where simultaneous ligation of the alpha- and beta-chains is essential for optimal response. These various modes of SED binding may be used to preserve bivalency regardless of variability in the MHC class II alpha/beta/peptide complexes."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Sundstroem M."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Sundstroem M."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Dohlsten M."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Dohlsten M."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Al-Daccak R."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Al-Daccak R."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Antonsson P."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Antonsson P."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Damdoumi F."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Damdoumi F."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Sekaly R.P."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Sekaly R.P."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Etongue-Mayer P."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Etongue-Mayer P."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Mehindate K."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Mehindate K."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Mourad W."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Mourad W."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Nilsson H."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/author | "Nilsson H."xsd:string |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9551975 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |