| http://purl.uniprot.org/citations/9557685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9557685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9557685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9557685 | http://www.w3.org/2000/01/rdf-schema#comment | "Simian virus 40 (SV40) DNAs in brain tissue and peripheral blood mononuclear cells (PBMCs) of eight simian immunodeficiency virus-infected rhesus monkeys with SV40 brain disease were analyzed. We report the detection, cloning, and identification of five new SV40 strains following a quadruple testing-verification strategy. SV40 genomes with archetypal regulatory regions (containing a duplication within the G/C-rich regulatory region segment and a single 72-bp enhancer element) were recovered from seven animal brains, two tissues of which also contained viral genomes with nonarchetypal regulatory regions (containing a duplication within the G/C-rich regulatory region segment as well as a variable duplication within the enhancer region). In contrast, PBMC DNAs from five of six animals had viral genomes with both regulatory region types. It appeared, based on T-antigen variable-region sequences, that nonarchetypal virus variants arose de novo within each animal. The eighth animal exclusively yielded a new type of SV40 strain (SV40-K661), containing a protoarchetypal regulatory region (lacking a duplication within the G/C-rich segment of the regulatory region and containing one 72-bp element in the enhancer region), from both brain tissue and PBMCs. The presence of SV40 in PBMCs suggests that hematogenous spread of viral infection may occur. An archetypal version of a virus similar to SV40 reference strain 776 (a kidney isolate) was recovered from one brain, substantiating the idea that SV40 is neurotropic as well as kidney-tropic. Indirect evidence suggests that maternal-infant transmission of SV40 may have occurred in one animal. These findings provide new insights for human polyomavirus disease."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.72.5.3980-3990.1998"xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Wong C."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Wong C."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Wong C."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Murphey-Corb M."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Murphey-Corb M."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Murphey-Corb M."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Stewart A.R."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Stewart A.R."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Stewart A.R."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Lednicky J.A."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Lednicky J.A."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Lednicky J.A."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Dai X.M."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Dai X.M."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Dai X.M."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Butel J.S."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Butel J.S."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Butel J.S."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Arrington A.S."xsd:string |
| http://purl.uniprot.org/citations/9557685 | http://purl.uniprot.org/core/author | "Arrington A.S."xsd:string |