| http://purl.uniprot.org/citations/9565608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9565608 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA strand breaks are potential interaction sites for the nuclear enzyme poly(ADP-ribose) polymerase (PARP; E.C. 2.4.2.30) and the tumor suppressor protein p53. Both proteins bind and respond to DNA breaks and both play a role in DNA damage signaling. A temporary colocalization and complex formation between these proteins has been demonstrated in mammalian cells. Here we show that free and poly(ADP-ribose) polymerase-bound ADP-ribose polymers target three domains in p53 protein for strong noncovalent interactions. The polymer binding sites could be mapped to two amino acid sequences in the sequence-specific core DNA binding domain of p53 (amino acid positions 153-178 and 231-253) and another one in the oligomerization domain (amino acids 326-348). In mobility shift experiments, poly(ADP-ribose) effectively prevented and reversed p53 binding to the palindromic p53 consensus sequence. Additionally, poly(ADP-ribose) also interfered with the DNA single strand end binding of p53. The results suggest that ADP-ribose polymers could play a role in regulating the DNA binding properties of p53."xsd:string |
| http://purl.uniprot.org/citations/9565608 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.19.11839"xsd:string |
| http://purl.uniprot.org/citations/9565608 | http://purl.uniprot.org/core/author | "Althaus F.R."xsd:string |
| http://purl.uniprot.org/citations/9565608 | http://purl.uniprot.org/core/author | "Kleczkowska H.E."xsd:string |
| http://purl.uniprot.org/citations/9565608 | http://purl.uniprot.org/core/author | "Malanga M."xsd:string |
| http://purl.uniprot.org/citations/9565608 | http://purl.uniprot.org/core/author | "Pleschke J.M."xsd:string |
| http://purl.uniprot.org/citations/9565608 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9565608 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/9565608 | http://purl.uniprot.org/core/pages | "11839-11843"xsd:string |
| http://purl.uniprot.org/citations/9565608 | http://purl.uniprot.org/core/title | "Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions."xsd:string |
| http://purl.uniprot.org/citations/9565608 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/9565608 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9565608 |
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| http://purl.uniprot.org/uniprot/#_A0A0A6YVX0-mappedCitation-9565608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9565608 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YX03-mappedCitation-9565608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9565608 |
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| http://purl.uniprot.org/uniprot/#_P11103-mappedCitation-9565608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9565608 |
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| http://purl.uniprot.org/uniprot/#_Q3TX36-mappedCitation-9565608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9565608 |
| http://purl.uniprot.org/uniprot/#_Q921K2-mappedCitation-9565608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9565608 |
| http://purl.uniprot.org/uniprot/#_Q3UJ03-mappedCitation-9565608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9565608 |
| http://purl.uniprot.org/uniprot/#_Q3TF18-mappedCitation-9565608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9565608 |
| http://purl.uniprot.org/uniprot/#_Q3TIV3-mappedCitation-9565608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9565608 |
| http://purl.uniprot.org/uniprot/#_Q3TM68-mappedCitation-9565608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9565608 |