| http://purl.uniprot.org/citations/9570008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9570008 | http://www.w3.org/2000/01/rdf-schema#comment | "We have examined the structure and function of Ca2+ channels in excitable endocrine cell types, in rat adrenal glomerulosa cells and in two insulin producing cell types, the rat pancreatic beta cell and the INS-1 cell line. In previous studies on glomerulosa cells, we observed low (T-type) and high threshold (L-type) voltage dependent Ca2+ currents in addition to a K+ induced inward rectifying Ca2+ current (Igl). beta cells are known to exhibit T-, L- and N-type currents. We have now found that INS-1 cells also show low threshold (T-type) and high threshold Ca2+ currents. The latter was further resolved by organic inhibitors into L-type and P/Q-type currents and no Igl was detected. The expression of the pore-forming alpha 1 subunit of voltage dependent Ca2+ channels was studied by means of reverse transcription-polymerase chain reaction (RT-PCR), followed by restriction enzyme mapping and/or sequencing. Both in glomerulosa and pancreatic beta cells, the neuroendocrine (D) class of the alpha 1 subunit, known to be responsible for L-type current, represents the majority of the PCR product. Comparable amounts of the neuroendocrine (D) and the neuronal A-type alpha 1 subunits dominate the message in INS-1 cells. Different characteristics of Ca2+ currents in these cell types is discussed in view of the channel repertoire."xsd:string |
| http://purl.uniprot.org/citations/9570008 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0143-4160(98)90072-0"xsd:string |
| http://purl.uniprot.org/citations/9570008 | http://purl.uniprot.org/core/author | "Enyedi P."xsd:string |
| http://purl.uniprot.org/citations/9570008 | http://purl.uniprot.org/core/author | "Horvath A."xsd:string |
| http://purl.uniprot.org/citations/9570008 | http://purl.uniprot.org/core/author | "Varnai P."xsd:string |
| http://purl.uniprot.org/citations/9570008 | http://purl.uniprot.org/core/author | "Wollheim C.B."xsd:string |
| http://purl.uniprot.org/citations/9570008 | http://purl.uniprot.org/core/author | "Aranyi T."xsd:string |
| http://purl.uniprot.org/citations/9570008 | http://purl.uniprot.org/core/author | "Szabadkai G."xsd:string |
| http://purl.uniprot.org/citations/9570008 | http://purl.uniprot.org/core/author | "Spat A."xsd:string |
| http://purl.uniprot.org/citations/9570008 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9570008 | http://purl.uniprot.org/core/name | "Cell Calcium"xsd:string |
| http://purl.uniprot.org/citations/9570008 | http://purl.uniprot.org/core/pages | "33-42"xsd:string |
| http://purl.uniprot.org/citations/9570008 | http://purl.uniprot.org/core/title | "Voltage dependent calcium channels in adrenal glomerulosa cells and in insulin producing cells."xsd:string |
| http://purl.uniprot.org/citations/9570008 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/9570008 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9570008 |
| http://purl.uniprot.org/citations/9570008 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9570008 |
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| http://purl.uniprot.org/uniprot/#_Q13936-mappedCitation-9570008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9570008 |
| http://purl.uniprot.org/uniprot/#_P16520-mappedCitation-9570008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9570008 |
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| http://purl.uniprot.org/uniprot/#_P50151-mappedCitation-9570008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9570008 |
| http://purl.uniprot.org/uniprot/#_Q08289-mappedCitation-9570008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9570008 |
| http://purl.uniprot.org/uniprot/#_Q01668-mappedCitation-9570008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9570008 |