| http://purl.uniprot.org/citations/9571170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9571170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9571170 | http://www.w3.org/2000/01/rdf-schema#comment | "Butein, a plant polyphenol, was shown to be a specific protein tyrosine kinase inhibitor. This compound inhibited not only the epidermal growth factor (EGF)-stimulated auto-phosphotyrosine level of EGF receptor in HepG2 cells but also tyrosine-specific protein kinase activities of EGF receptor (IC50 = 65 microM) and p60c-src (IC50 = 65 microM) in vitro. The inhibition was competitive to ATP and non-competitive to the phosphate acceptor, poly (Glu, Ala, Tyr) 6:3:1 for EGF receptor tyrosine kinase. In contrast, butein non-significantly inhibited the activities of serine- and threonine-specific protein kinases, such as protein kinase C (PKC) and cAMP-dependent protein kinase (PKA)."xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1998.8452"xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1998.8452"xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/author | "Zhang K."xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/author | "Zhang K."xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/author | "Cheng L.Y."xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/author | "Cheng L.Y."xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/author | "Mack P."xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/author | "Mack P."xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/author | "Yang E.B."xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/author | "Yang E.B."xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/pages | "435-438"xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/pages | "435-438"xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/title | "Butein, a specific protein tyrosine kinase inhibitor."xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/title | "Butein, a specific protein tyrosine kinase inhibitor."xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/volume | "245"xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://purl.uniprot.org/core/volume | "245"xsd:string |
| http://purl.uniprot.org/citations/9571170 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9571170 |
| http://purl.uniprot.org/citations/9571170 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9571170 |