| http://purl.uniprot.org/citations/9576833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9576833 | http://www.w3.org/2000/01/rdf-schema#comment | "Elongation and branching of epithelial ducts is a crucial event during the development of the mammary gland. Branching morphogenesis of the mouse mammary epithelial TAC-2 cell line was used as an assay to examine the role of Wnt, HGF, TGF-beta, and the Notch receptors in branching morphogenesis. Wnt-1 was found to induce the elongation and branching of epithelial tubules, like HGF and TGF-beta 2, and to strongly cooperate with either HGF or TGF-beta 2 in this activity. Wnt-1 displayed morphogenetic activity in TAC-2 cells as it induced branching even under conditions that normally promote cyst formation. The Notch4(int-3) mammary oncoprotein, an activated form of the Notch4 receptor, inhibited the branching morphogenesis normally induced by HGF and TGF-beta 2. The minimal domain within the Notch4(int-3) protein required to inhibit morphogenesis consists of the CBF-1 interaction domain and the cdc10 repeat domain. Coexpression of Wnt-1 and Notch4(int-3) demonstrates that Wnt-1 can overcome the Notch-mediated inhibition of branching morphogenesis. These data suggest that Wnt and Notch signaling may play opposite roles in mammary gland development, a finding consistent with the convergence of the wingless and Notch signaling pathways found in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/9576833 | http://purl.org/dc/terms/identifier | "doi:10.1006/dbio.1998.8863"xsd:string |
| http://purl.uniprot.org/citations/9576833 | http://purl.uniprot.org/core/author | "Kitajewski J."xsd:string |
| http://purl.uniprot.org/citations/9576833 | http://purl.uniprot.org/core/author | "Montesano R."xsd:string |
| http://purl.uniprot.org/citations/9576833 | http://purl.uniprot.org/core/author | "Uyttendaele H."xsd:string |
| http://purl.uniprot.org/citations/9576833 | http://purl.uniprot.org/core/author | "Soriano J.V."xsd:string |
| http://purl.uniprot.org/citations/9576833 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9576833 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/9576833 | http://purl.uniprot.org/core/pages | "204-217"xsd:string |
| http://purl.uniprot.org/citations/9576833 | http://purl.uniprot.org/core/title | "Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion."xsd:string |
| http://purl.uniprot.org/citations/9576833 | http://purl.uniprot.org/core/volume | "196"xsd:string |
| http://purl.uniprot.org/citations/9576833 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9576833 |
| http://purl.uniprot.org/citations/9576833 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9576833 |
| http://purl.uniprot.org/uniprot/Q99466#attribution-7675044BCFF11E4C0CA34D7CDC2055CB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9576833 |
| http://purl.uniprot.org/uniprot/#_B2RQR1-mappedCitation-9576833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9576833 |
| http://purl.uniprot.org/uniprot/#_G3UZH3-mappedCitation-9576833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9576833 |
| http://purl.uniprot.org/uniprot/#_G3UX69-mappedCitation-9576833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9576833 |
| http://purl.uniprot.org/uniprot/#_Q3UR96-mappedCitation-9576833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9576833 |
| http://purl.uniprot.org/uniprot/#_P04426-mappedCitation-9576833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9576833 |
| http://purl.uniprot.org/uniprot/#_P31695-mappedCitation-9576833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9576833 |
| http://purl.uniprot.org/uniprot/B2RQR1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9576833 |
| http://purl.uniprot.org/uniprot/P31695 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9576833 |
| http://purl.uniprot.org/uniprot/G3UX69 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9576833 |
| http://purl.uniprot.org/uniprot/P04426 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9576833 |