| http://purl.uniprot.org/citations/9576836 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9576836 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular events of cardiac lineage specification and differentiation are largely unknown. Here we describe the involvement of a growth factor with an EGF-like domain, Cripto-1 (Cr-1), in cardiac differentiation. During embryonic development, Cr-1 is expressed in the mouse blastocyst, primitive streak, and later is restricted to the developing heart. To investigate the role of Cr-1, we have generated Cr-1-negative embryonic stem (ES) cell lines by homologous recombination. The resulting double "knockout" ES cells have selectively lost the ability to form beating cardiac myocytes, a process that can be rescued by reintroducing Cr-1 gene back into the Cr(-/-) cells. Furthermore, the lack of functional Cr-1 is correlated with absence of expression of cardiac-specific myosin light and heavy chain genes during differentiation. Differentiation into other cell types including skeletal muscle is not disrupted. These results suggest that Cr-1 is essential for contractile cardiomyocyte formation in vitro."xsd:string |
| http://purl.uniprot.org/citations/9576836 | http://purl.org/dc/terms/identifier | "doi:10.1006/dbio.1998.8862"xsd:string |
| http://purl.uniprot.org/citations/9576836 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/9576836 | http://purl.uniprot.org/core/author | "Adamson E.D."xsd:string |
| http://purl.uniprot.org/citations/9576836 | http://purl.uniprot.org/core/author | "Persico M.G."xsd:string |
| http://purl.uniprot.org/citations/9576836 | http://purl.uniprot.org/core/author | "Liguori G."xsd:string |
| http://purl.uniprot.org/citations/9576836 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9576836 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/9576836 | http://purl.uniprot.org/core/pages | "237-247"xsd:string |
| http://purl.uniprot.org/citations/9576836 | http://purl.uniprot.org/core/title | "Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1."xsd:string |
| http://purl.uniprot.org/citations/9576836 | http://purl.uniprot.org/core/volume | "196"xsd:string |
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