| http://purl.uniprot.org/citations/9584101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9584101 | http://www.w3.org/2000/01/rdf-schema#comment | "We used the white gene as an enhancer trap and reporter of chromatin structure. We collected white+ transgene insertions presenting a peculiar pigmentation pattern in the eye: white expression is restricted to the dorsal half of the eye, with a clear-cut dorsal/ventral (D/V) border. This D/V pattern is stable and heritable, indicating that phenotypic expression of the white reporter reflects positional information in the developing eye. Localization of these transgenes led us to identify a unique genomic region encompassing 140 kb in 69D1-3 subject to this D/V effect. This region contains at least three closely related homeobox-containing genes that are constituents of the iroquois complex (IRO-C). IRO-C genes are coordinately regulated and implicated in similar developmental processes. Expression of these genes in the eye is regulated by the products of the Polycomb-group (Pc-G) and trithorax-group (trx-G) genes but is not modified by classical modifiers of position-effect variegation. Our results, together with the report of a Pc-G binding site in 69D, suggest that we have identified a novel cluster of target genes for the Pc-G and trx-G products. We thus propose that ventral silencing of the whole IRO-C in the eye occurs at the level of chromatin structure in a manner similar to that of the homeotic gene complexes, perhaps by local compaction of the region into a heterochromatin-like structure involving the Pc-G products."xsd:string |
| http://purl.uniprot.org/citations/9584101 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/149.1.257"xsd:string |
| http://purl.uniprot.org/citations/9584101 | http://purl.uniprot.org/core/author | "Fauvarque M.O."xsd:string |
| http://purl.uniprot.org/citations/9584101 | http://purl.uniprot.org/core/author | "Netter S."xsd:string |
| http://purl.uniprot.org/citations/9584101 | http://purl.uniprot.org/core/author | "Dura J.M."xsd:string |
| http://purl.uniprot.org/citations/9584101 | http://purl.uniprot.org/core/author | "Diez del Corral R."xsd:string |
| http://purl.uniprot.org/citations/9584101 | http://purl.uniprot.org/core/author | "Coen D."xsd:string |
| http://purl.uniprot.org/citations/9584101 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9584101 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/9584101 | http://purl.uniprot.org/core/pages | "257-275"xsd:string |
| http://purl.uniprot.org/citations/9584101 | http://purl.uniprot.org/core/title | "white+ transgene insertions presenting a dorsal/ventral pattern define a single cluster of homeobox genes that is silenced by the polycomb-group proteins in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/9584101 | http://purl.uniprot.org/core/volume | "149"xsd:string |
| http://purl.uniprot.org/citations/9584101 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9584101 |
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| http://purl.uniprot.org/uniprot/O01667#attribution-60EC113D0691C0E5B7D429DB1CDCEA43 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9584101 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KET9-mappedCitation-9584101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9584101 |