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http://purl.uniprot.org/citations/9593162http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9593162http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9593162http://www.w3.org/2000/01/rdf-schema#comment"The sequence of the gene encoding a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-4) was determined. It was located in a plasmid harbored by a Salmonella typhimurium strain. CTX-M-4 was similar to the plasmidic cefotaxime-hydrolyzing beta-lactamases CTX-M-2 and Toho-1 and related to the chromosomal beta-lactamase of Klebsiella oxytoca. A Ser-237-->Ala substitution, introduced by site-directed mutagenesis, caused minor alterations in the interaction of CTX-M-4 with beta-lactams, reducing slightly the relative hydrolytic activity against cefotaxime and the susceptibility to inhibition by clavulanate."xsd:string
http://purl.uniprot.org/citations/9593162http://purl.org/dc/terms/identifier"doi:10.1128/aac.42.5.1259"xsd:string
http://purl.uniprot.org/citations/9593162http://purl.org/dc/terms/identifier"doi:10.1128/aac.42.5.1259"xsd:string
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/author"Gazouli M."xsd:string
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/author"Gazouli M."xsd:string
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/author"Sidorenko S.V."xsd:string
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/author"Sidorenko S.V."xsd:string
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/author"Tzelepi E."xsd:string
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/author"Tzelepi E."xsd:string
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/author"Tzouvelekis L.S."xsd:string
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/author"Tzouvelekis L.S."xsd:string
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/name"Antimicrob. Agents Chemother."xsd:string
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/name"Antimicrob. Agents Chemother."xsd:string
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/pages"1259-1262"xsd:string
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/pages"1259-1262"xsd:string
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/title"Sequence of the gene encoding a plasmid-mediated cefotaxime-hydrolyzing class A beta-lactamase (CTX-M-4): involvement of serine 237 in cephalosporin hydrolysis."xsd:string
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/title"Sequence of the gene encoding a plasmid-mediated cefotaxime-hydrolyzing class A beta-lactamase (CTX-M-4): involvement of serine 237 in cephalosporin hydrolysis."xsd:string
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/volume"42"xsd:string
http://purl.uniprot.org/citations/9593162http://purl.uniprot.org/core/volume"42"xsd:string
http://purl.uniprot.org/citations/9593162http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9593162
http://purl.uniprot.org/citations/9593162http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9593162