| http://purl.uniprot.org/citations/9593684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9593684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9593684 | http://www.w3.org/2000/01/rdf-schema#comment | "C/EBPepsilon is a member of the CCAAT/enhancer binding protein family of basic region/leucine zipper transcriptional activators. The C/EBPepsilon protein is highly conserved between rodents and humans, and its domain structure is very similar to C/EBPalpha. In mice C/EBPepsilon mRNA is only detected in hematopoietic tissues, including embryonic liver and adult bone marrow and spleen. Within the hematopoietic system, C/EBPepsilon is expressed primarily in myeloid cells, including promyelocytes, myelomonocytes, and their differentiated progeny. To identify potential functions of C/EBPepsilon, cell lines over-expressing the C/EBPepsilon protein were generated in the P388 lymphoblastic cell line. In contrast to the parental cell line, C/EBPepsilon-expressing cell lines displayed lipopolysaccharide-inducible expression of the interleukin-6 and monocyte chemoattractant protein 1 (MCP-1) genes as well as elevated basal expression of the MIP-1alpha and MIP-1beta chemokine genes. In the EML-C1 hematopoietic stem cell line, C/EBPepsilon mRNA levels increased as the cells progressed along the myeloid lineage, just preceding activation of the gene encoding the receptor for macrophage-colony-stimulating factor (M-CSFR). M-CSFR expression was stimulated in C/EBPepsilon-expressing P388 cell lines, when compared with either the parental P388 cells or P388 cell lines expressing either C/EBPalpha or C/EBPbeta. These results suggest that C/EBPepsilon may be an important regulator of differentiation of a subset of myeloid cell types and may also participate in the regulation of cytokine gene expression in mature cells."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.22.13493"xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.22.13493"xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/author | "Du Y."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/author | "Du Y."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/author | "Ortiz M."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/author | "Ortiz M."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/author | "Williams S.C."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/author | "Williams S.C."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/author | "Keller J.R."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/author | "Keller J.R."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/author | "Schwartz R.C."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/author | "Schwartz R.C."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/author | "Johnson P.F."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/author | "Johnson P.F."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/author | "Weiler S.R."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/author | "Weiler S.R."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/pages | "13493-13501"xsd:string |
| http://purl.uniprot.org/citations/9593684 | http://purl.uniprot.org/core/pages | "13493-13501"xsd:string |