| http://purl.uniprot.org/citations/9593748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9593748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9593748 | http://www.w3.org/2000/01/rdf-schema#comment | "Human chromosome 17-specific genomic clones extending over 90 kilobases (kb) of DNA and coding for sarco/endoplasmic reticulum Ca2+-ATPase 3 (SERCA3) were isolated. The presence of the D17S1828 genetic marker in the cosmid contig enabled us to map the SERCA3 gene (ATP2A3) 11 centimorgans from the top of the short arm p of chromosome 17, in the vicinity of the cystinosis gene locus. The SERCA3 gene contains 22 exons spread over 50 kb of genomic DNA. The exon/intron boundaries are well conserved between human SERCA3 and SERCA1 genes, except for the junction between exons 8 and 9 which is found in the SERCA1 gene but not in SERCA3 and SERCA2 genes. The transcription start site (+1) is located 152 nucleotides (nt) upstream of the AUG codon. The 5'-flanking region, including exon 1, is embedded in a 1.5-kb CpG island and is characterized by the absence of a TATA box and by the presence of 14 putative Sp1 sites, 11 CACCC boxes, 5 AP-2-binding motifs, 3 GGCTGGGG motifs, 3 CANNTG boxes, a GATA motif, as well as single sites for Ets-1, c-Myc, and TFIIIc. Functional promoter analysis indicated that the GC-rich region (87% G + C) from -135 to -31 is of critical importance in initiating SERCA3 gene transcription in Jurkat cells. Exon 21 (human, 101 base pairs; mouse, 86 base pairs) can be alternatively excluded, partially included, or totally included, thus generating, respectively, SERCA3a (human and mouse, 999 amino acids (aa)), SERCA3b (human, 1043 aa; mouse, 1038 aa), or SERCA3c (human, 1024 aa; mouse, 1021 aa) isoforms with different C termini. Expression of the mouse SERCA3 isoforms in COS-1 cells demonstrated their ability to function as active pumps, although with different apparent affinities for Ca2+."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.22.13982"xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.22.13982"xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/author | "Wuytack F."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/author | "Wuytack F."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/author | "Attard M."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/author | "Attard M."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/author | "Casteels R."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/author | "Casteels R."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/author | "De Greef C."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/author | "De Greef C."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/author | "Dode L."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/author | "Dode L."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/author | "Mountian I."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/author | "Mountian I."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/author | "Town M.M."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/author | "Town M.M."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/pages | "13982-13994"xsd:string |
| http://purl.uniprot.org/citations/9593748 | http://purl.uniprot.org/core/pages | "13982-13994"xsd:string |