| http://purl.uniprot.org/citations/9600074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9600074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9600074 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular endothelial growth factor (VEGF) binds to its receptor tyrosine kinase Flt-1 and KDR/Flk-1 and stimulates their autophosphorylation. However, little is known about their downstream signal transduction properties. We examined the interactions of certain proteins with a SH2-domain with Flt-1 and KDR using the yeast two-hybrid system and found that Nck, SHP-2, PLC gamma, and PI3K p85 bind to Flt-1. Extensive site-directed mutagenesis of Flt-1 revealed their major binding sites. Nck, SHP-2, and PI3K bind to Y1213 of Flt-1. Nck also binds to Y1333 of Flt-1. These results suggest that Nck, SHP-2, PLC gamma, and PI3K play important roles in Flt-1 signal transduction and that Y1213 of Flt-1 is a major binding site of PI3K, Nck, and SHP-2."xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1998.8578"xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1998.8578"xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/author | "Igarashi K."xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/author | "Igarashi K."xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/author | "Kato T."xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/author | "Kato T."xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/author | "Shigeta K."xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/author | "Shigeta K."xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/author | "Isohara T."xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/author | "Isohara T."xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/author | "Uno I."xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/author | "Uno I."xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/author | "Yamano T."xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/author | "Yamano T."xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/pages | "95-99"xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/pages | "95-99"xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/title | "Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2."xsd:string |
| http://purl.uniprot.org/citations/9600074 | http://purl.uniprot.org/core/title | "Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2."xsd:string |