| http://purl.uniprot.org/citations/9603981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9603981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9603981 | http://www.w3.org/2000/01/rdf-schema#comment | "Classical A kinase anchor proteins (AKAPs) preferentially tether type II protein kinase A (PKAII) isoforms to sites in the cytoskeleton and organelles. It is not known if distinct proteins selectively sequester regulatory (R) subunits of type I PKAs, thereby diversifying functions of these critical enzymes. In Caenorhabditis elegans, a single type I PKA mediates all aspects of cAMP signaling. We have discovered a cDNA that encodes a binding protein (AKAPCE) for the regulatory subunit (RCE) of C. elegans PKAICE. AKAPCE is a novel, highly acidic RING finger protein composed of 1,280 amino acids. It binds RI-like RCE with high affinity and neither RIIalpha nor RIIbeta competitively inhibits formation of AKAPCE.RCE complexes. The RCE-binding site was mapped to a segment of 20 amino acids in an N-terminal region of AKAPCE. Several hydrophobic residues in the binding site align with essential Leu and Ile residues in the RII-selective tethering domain of prototypic mammalian AKAPs. However, the RCE-binding region in AKAPCE diverges sharply from consensus RII-binding sites by inclusion of three aromatic amino acids, exclusion of a highly conserved Leu or Ile at position 8 and replacement of C-terminal hydrophobic amino acids with basic residues. AKAPCE.RCE complexes accumulate in intact cells."xsd:string |
| http://purl.uniprot.org/citations/9603981 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.23.14633"xsd:string |
| http://purl.uniprot.org/citations/9603981 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.23.14633"xsd:string |
| http://purl.uniprot.org/citations/9603981 | http://purl.uniprot.org/core/author | "Rubin C.S."xsd:string |
| http://purl.uniprot.org/citations/9603981 | http://purl.uniprot.org/core/author | "Rubin C.S."xsd:string |
| http://purl.uniprot.org/citations/9603981 | http://purl.uniprot.org/core/author | "Angelo R."xsd:string |
| http://purl.uniprot.org/citations/9603981 | http://purl.uniprot.org/core/author | "Angelo R."xsd:string |
| http://purl.uniprot.org/citations/9603981 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9603981 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9603981 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9603981 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/9603981 | http://purl.uniprot.org/core/pages | "14633-14643"xsd:string |
| http://purl.uniprot.org/citations/9603981 | http://purl.uniprot.org/core/pages | "14633-14643"xsd:string |
| http://purl.uniprot.org/citations/9603981 | http://purl.uniprot.org/core/title | "Molecular characterization of an anchor protein (AKAPCE) that binds the RI subunit (RCE) of type I protein kinase A from Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/9603981 | http://purl.uniprot.org/core/title | "Molecular characterization of an anchor protein (AKAPCE) that binds the RI subunit (RCE) of type I protein kinase A from Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/9603981 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/9603981 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/9603981 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9603981 |
| http://purl.uniprot.org/citations/9603981 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9603981 |
| http://purl.uniprot.org/citations/9603981 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9603981 |
| http://purl.uniprot.org/citations/9603981 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9603981 |
| http://purl.uniprot.org/uniprot/Q18930 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9603981 |
| http://purl.uniprot.org/uniprot/#_Q18930-citation-9603981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9603981 |