| http://purl.uniprot.org/citations/9604932 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9604932 | http://www.w3.org/2000/01/rdf-schema#comment | "The let-23 receptor/mpk-1 MAP kinase signaling pathway induces the vulva in C. elegans. We show that MPK-1 directly regulates both the LIN-31 winged-helix and the LIN-1 Ets transcription factors to specify the vulval cell fate. lin-31 and lin-1 act genetically downstream of mpk-1, and both proteins can be directly phosphorylated by MAP kinase. LIN-31 binds to LIN-1, and the LIN-1/LIN-31 complex inhibits vulval induction. Phosphorylation of LIN-31 by MPK-1 disrupts the LIN-1/LIN-31 complex, relieving vulval inhibition. Phosphorylated LIN-31 may also act as a transcriptional activator, promoting vulval cell fates. LIN-31 is a vulval-specific effector of MPK-1, while LIN-1 acts as a general effector. The partnership of tissue-specific and general effectors may confer specificity onto commonly used signaling pathways, creating distinct tissue-specific outcomes."xsd:string |
| http://purl.uniprot.org/citations/9604932 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81186-1"xsd:string |
| http://purl.uniprot.org/citations/9604932 | http://purl.uniprot.org/core/author | "Kim S.K."xsd:string |
| http://purl.uniprot.org/citations/9604932 | http://purl.uniprot.org/core/author | "Lackner M.R."xsd:string |
| http://purl.uniprot.org/citations/9604932 | http://purl.uniprot.org/core/author | "Tan P.B."xsd:string |
| http://purl.uniprot.org/citations/9604932 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9604932 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9604932 | http://purl.uniprot.org/core/pages | "569-580"xsd:string |
| http://purl.uniprot.org/citations/9604932 | http://purl.uniprot.org/core/title | "MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction."xsd:string |
| http://purl.uniprot.org/citations/9604932 | http://purl.uniprot.org/core/volume | "93"xsd:string |
| http://purl.uniprot.org/citations/9604932 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9604932 |
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