| http://purl.uniprot.org/citations/9605766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9605766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9605766 | http://www.w3.org/2000/01/rdf-schema#comment | "The isolation of genes involved in cancer development is critical for uncovering the molecular basis of cancer. We report here the isolation of the full-length cDNA and chromosomal localization of a new gene frequently deleted in liver cancer (DLC-1) that was identified by representational difference analysis. Loss of heterozygosity was detected for DLC-1 in 7 of 16 primary hepatocellular carcinomas (HCCs) and in 10 of 11 HCC cell lines. Although mRNA for DLC-1 was expressed in all normal human tissues, it was not expressed in 4 of 14 HCC cell lines. Full-length cDNA for DLC-1 of 3800 bp encodes a protein of 1091 amino acids, has 86% homology with rat p122 RhoGAP gene, and was localized by fluorescence in situ hybridization on chromosome 8 at bands p21.3-22. Deletions on the short arm of chromosome 8 are recurrent in liver, breast, lung, and prostate cancers, suggesting the presence of tumor suppressor genes. DLC-1 may be a tumor suppressor gene in liver cancer as well as in other cancers."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/author | "Miller M.J."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/author | "Miller M.J."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/author | "Popescu N.C."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/author | "Popescu N.C."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/author | "Zimonjic D.B."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/author | "Zimonjic D.B."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/author | "Thorgeirsson S.S."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/author | "Thorgeirsson S.S."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/author | "Keck C.L."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/author | "Keck C.L."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/author | "Yuan B.Z."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/author | "Yuan B.Z."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/pages | "2196-2199"xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/pages | "2196-2199"xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/title | "Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/title | "Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP."xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/volume | "58"xsd:string |
| http://purl.uniprot.org/citations/9605766 | http://purl.uniprot.org/core/volume | "58"xsd:string |