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http://purl.uniprot.org/citations/9607915http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9607915http://www.w3.org/2000/01/rdf-schema#comment"To investigate the possible involvement of DNA repair in the process of somatic hypermutation of rearranged immunoglobulin variable (V) region genes, we have analyzed the occurrence, frequency, distribution, and pattern of mutations in rearranged Vlambda1 light chain genes from naive and memory B cells in DNA repair-deficient mutant mouse strains. Hypermutation was found unaffected in mice carrying mutations in either of the following DNA repair genes: xeroderma pigmentosum complementation group (XP)A and XPD, Cockayne syndrome complementation group B (CSB), mutS homologue 2 (MSH2), radiation sensitivity 54 (RAD54), poly (ADP-ribose) polymerase (PARP), and 3-alkyladenine DNA-glycosylase (AAG). These results indicate that both subpathways of nucleotide excision repair, global genome repair, and transcription-coupled repair are not required for somatic hypermutation. This appears also to be true for mismatch repair, RAD54-dependent double-strand-break repair, and AAG-mediated base excision repair."xsd:string
http://purl.uniprot.org/citations/9607915http://purl.org/dc/terms/identifier"doi:10.1084/jem.187.11.1735"xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/author"Engelward B.P."xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/author"Samson L."xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/author"de Wind N."xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/author"Fukita Y."xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/author"Weeda G."xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/author"te Riele H."xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/author"Essers J."xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/author"van der Horst G.T."xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/author"Jacobs H."xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/author"de Murcia G."xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/author"Rajewsky K."xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/author"de Boer J."xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/author"Verbeek S."xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/author"de Murcia J.M."xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/name"J Exp Med"xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/pages"1735-1743"xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/title"Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice."xsd:string
http://purl.uniprot.org/citations/9607915http://purl.uniprot.org/core/volume"187"xsd:string
http://purl.uniprot.org/citations/9607915http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9607915
http://purl.uniprot.org/citations/9607915http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9607915
http://purl.uniprot.org/uniprot/#_A0A0A6YVX0-mappedCitation-9607915http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9607915