| http://purl.uniprot.org/citations/9607925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9607925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9607925 | http://www.w3.org/2000/01/rdf-schema#comment | "4-1BB ligand (4-1BBL) is a member of the tumor necrosis factor (TNF) family expressed on activated antigen-presenting cells. Its receptor, 4-1BB, is a member of the TNF receptor family expressed on activated CD4 and CD8 T cells. We have produced a soluble form of 4-1BBL using the baculovirus expression system. When coimmobilized on plastic with anti-CD3, soluble 4-1BBL induces interleukin (IL)-2 production by resting CD28+ or CD28-T cells, indicating that 4-1BBL can function independently of other cell surface molecules, including CD28, in costimulation of resting T cell activation. At low concentrations of anti-CD3, 4-1BBL is inferior to anti-CD28 in T cell activation. However, when 4-1BB ligand is provided together with strong TCR signals, then 4-1BBL and anti-CD28 are equally potent in stimulation of IL-2 production by resting T cells. We find that TNF receptor-associated factor (TRAF)1 or TRAF2 associate with a glutathione S-transferase-4-1BB cytoplasmic domain fusion protein in vitro. In T cells, we find that association of TRAF1 and TRAF2 with 4-1BB requires 4-1BB cross-linking. In support of a functional role for TRAF2 in 4-1BB signaling, we find that resting T cells isolated from TRAF2-deficient mice or from mice expressing a dominant negative form of TRAF2 fail to augment IL-2 production in response to soluble 4-1BBL. Thus 4-1BB, via the TRAF2 molecule, can provide CD28-independent costimulatory signals to resting T cells."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.187.11.1849"xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.187.11.1849"xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Lee S.Y."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Lee S.Y."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Choi Y."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Choi Y."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Mak T.W."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Mak T.W."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Santana A."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Santana A."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Cannons J.L."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Cannons J.L."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Yeh W.C."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Yeh W.C."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Watts T.H."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Watts T.H."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Bangia N."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Bangia N."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Goldstein M.D."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "Goldstein M.D."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "DeBenedette M.A."xsd:string |
| http://purl.uniprot.org/citations/9607925 | http://purl.uniprot.org/core/author | "DeBenedette M.A."xsd:string |