| http://purl.uniprot.org/citations/9611253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9611253 | http://www.w3.org/2000/01/rdf-schema#comment | "17beta-Estradiol (E2) induces cathepsin D gene expression in MCF-7 human breast cancer cells and previous analyses of the proximal promoter region of this gene identified two functional enhancer sequences; namely an Sp1(N)23estrogen-responsive element (ERE) half-site (-199 to -165) and an imperfect palindromic ERE (-119 to -107). A third region of the cathepsin D gene promoter (CD/L, -145 to -119) was also E2 responsive in transient transfection assays. A GC-rich sequence which contains two overlapping Sp1 binding sites (-145 to -135) was responsible for ER-mediated transactivation and required formation of an ER/Sp1 complex in which only the Sp1 protein bound DNA. E2 responsiveness of the CD/L sequence was also dependent on an adjacent overlapping GCGTG motif corresponding to the dioxin-responsive element (DRE) core binding sequence, which is the cognate response element for the heterodimeric aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) transcription factor complex. The results show that ER-mediated transactivation of CD/L was associated with the Sp1(N)2-4DRE (core) motif and involved formation of a multiprotein ER/Sp1-AhR/ARNT complex. These results illustrate a unique example of an endogenous role for AhR/ARNT in the absence of added AhR agonist and indicate that the cathepsin D gene proximal promoter region contains at least three different functional motifs associated with ER-mediated transactivation."xsd:string |
| http://purl.uniprot.org/citations/9611253 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/26.12.3044"xsd:string |
| http://purl.uniprot.org/citations/9611253 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/9611253 | http://purl.uniprot.org/core/author | "Hoivik D."xsd:string |
| http://purl.uniprot.org/citations/9611253 | http://purl.uniprot.org/core/author | "Safe S."xsd:string |
| http://purl.uniprot.org/citations/9611253 | http://purl.uniprot.org/core/author | "Pollenz R."xsd:string |
| http://purl.uniprot.org/citations/9611253 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9611253 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/9611253 | http://purl.uniprot.org/core/pages | "3044-3052"xsd:string |
| http://purl.uniprot.org/citations/9611253 | http://purl.uniprot.org/core/title | "Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes."xsd:string |
| http://purl.uniprot.org/citations/9611253 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/9611253 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9611253 |
| http://purl.uniprot.org/citations/9611253 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9611253 |
| http://purl.uniprot.org/uniprot/#_Q15596-mappedCitation-9611253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9611253 |
| http://purl.uniprot.org/uniprot/#_Q15648-mappedCitation-9611253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9611253 |
| http://purl.uniprot.org/uniprot/#_P03372-mappedCitation-9611253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9611253 |
| http://purl.uniprot.org/uniprot/#_P08047-mappedCitation-9611253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9611253 |
| http://purl.uniprot.org/uniprot/#_Q15788-mappedCitation-9611253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9611253 |
| http://purl.uniprot.org/uniprot/#_P22415-mappedCitation-9611253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9611253 |
| http://purl.uniprot.org/uniprot/#_Q09472-mappedCitation-9611253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9611253 |
| http://purl.uniprot.org/uniprot/#_Q15853-mappedCitation-9611253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9611253 |
| http://purl.uniprot.org/uniprot/#_Q9Y6Q9-mappedCitation-9611253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9611253 |
| http://purl.uniprot.org/uniprot/Q15596 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9611253 |
| http://purl.uniprot.org/uniprot/Q09472 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9611253 |