| http://purl.uniprot.org/citations/9616112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9616112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9616112 | http://www.w3.org/2000/01/rdf-schema#comment | "The mouse Clock gene encodes a bHLH-PAS protein that regulates circadian rhythms and is related to transcription factors that act as heterodimers. Potential partners of CLOCK were isolated in a two-hybrid screen, and one, BMAL1, was coexpressed with CLOCK and PER1 at known circadian clock sites in brain and retina. CLOCK-BMAL1 heterodimers activated transcription from E-box elements, a type of transcription factor-binding site, found adjacent to the mouse per1 gene and from an identical E-box known to be important for per gene expression in Drosophila. Mutant CLOCK from the dominant-negative Clock allele and BMAL1 formed heterodimers that bound DNA but failed to activate transcription. Thus, CLOCK-BMAL1 heterodimers appear to drive the positive component of per transcriptional oscillations, which are thought to underlie circadian rhythmicity."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.280.5369.1564"xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.280.5369.1564"xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/author | "Gekakis N."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/author | "Gekakis N."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/author | "Davis F.C."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/author | "Davis F.C."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/author | "Nguyen H.B."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/author | "Nguyen H.B."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/author | "King D.P."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/author | "King D.P."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/author | "Staknis D."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/author | "Staknis D."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/author | "Takahashi J.S."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/author | "Takahashi J.S."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/author | "Weitz C.J."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/author | "Weitz C.J."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/author | "Wilsbacher L.D."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/author | "Wilsbacher L.D."xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/9616112 | http://purl.uniprot.org/core/name | "Science"xsd:string |