| http://purl.uniprot.org/citations/9618507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9618507 | http://www.w3.org/2000/01/rdf-schema#comment | "SEK1 (MKK4/JNKK) is a mitogen-activated protein kinase activator that has been shown to participate in vitro in two stress-activated cascades terminating with the SAPK and p38 kinases. To define the role of SEK1 in vivo, we studied stress-induced signaling in SEK1(-/-) embryonic stem and fibroblast cells and evaluated the phenotype of SEK1(-/-) mouse embryos during development. Studies of SEK1(-/-) embryonic stem cells demonstrated defects in stimulated SAPK phosphorylation but not in the phosphorylation of p38 kinase. In contrast, SEK1(-/-) fibroblasts exhibited defects in both SAPK and p38 phosphorylation, demonstrating that crosstalk exists between the stress-activated cascades. Tumor necrosis factor alpha and interleukin 1 stimulation of both stress-activated cascades are severely affected in the SEK1(-/-) fibroblast cells. SEK1 deficiency leads to embryonic lethality after embryonic day 12.5 and is associated with abnormal liver development. This phenotype is similar to c-jun null mouse embryos and suggests that SEK1 is required for phosphorylation and activation of c-jun during the organo-genesis of the liver."xsd:string |
| http://purl.uniprot.org/citations/9618507 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.12.6881"xsd:string |
| http://purl.uniprot.org/citations/9618507 | http://purl.uniprot.org/core/author | "Fujiwara Y."xsd:string |
| http://purl.uniprot.org/citations/9618507 | http://purl.uniprot.org/core/author | "Ikeda T."xsd:string |
| http://purl.uniprot.org/citations/9618507 | http://purl.uniprot.org/core/author | "Zon L.I."xsd:string |
| http://purl.uniprot.org/citations/9618507 | http://purl.uniprot.org/core/author | "Perkins A."xsd:string |
| http://purl.uniprot.org/citations/9618507 | http://purl.uniprot.org/core/author | "Labow M.A."xsd:string |
| http://purl.uniprot.org/citations/9618507 | http://purl.uniprot.org/core/author | "Kwee L."xsd:string |
| http://purl.uniprot.org/citations/9618507 | http://purl.uniprot.org/core/author | "Ganiatsas S."xsd:string |
| http://purl.uniprot.org/citations/9618507 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9618507 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/9618507 | http://purl.uniprot.org/core/pages | "6881-6886"xsd:string |
| http://purl.uniprot.org/citations/9618507 | http://purl.uniprot.org/core/title | "SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis."xsd:string |
| http://purl.uniprot.org/citations/9618507 | http://purl.uniprot.org/core/volume | "95"xsd:string |
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