| http://purl.uniprot.org/citations/9628876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9628876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9628876 | http://www.w3.org/2000/01/rdf-schema#comment | "NSD1, a novel 2588 amino acid mouse nuclear protein that interacts directly with the ligand-binding domain (LBD) of several nuclear receptors (NRs), has been identified and characterized. NSD1 contains a SET domain and multiple PHD fingers. In addition to these conserved domains found in both positive and negative Drosophila chromosomal regulators, NSD1 contains two distinct NR interaction domains, NID-L and NID+L, that exhibit binding properties of NIDs found in NR corepressors and coactivators, respectively. NID-L, but not NID+L, interacts with the unliganded LBDs of retinoic acid receptors (RAR) and thyroid hormone receptors (TR), and this interaction is severely impaired by mutations in the LBD alpha-helix 1 that prevent binding of corepressors and transcriptional silencing by apo-NRs. NID+L, but not NID-L, interacts with the liganded LBDs of RAR, TR, retinoid X receptor (RXR), and estrogen receptor (ER), and this interaction is abrogated by mutations in the LBD alpha-helix 12 that prevent binding of coactivators of the ligand-induced transcriptional activation function AF-2. A novel variant (FxxLL) of the NR box motif (LxxLL) is present in NID+L and is required for the binding of NSD1 to holo-LBDs. Interestingly, NSD1 contains separate repression and activation domains. Thus, NSD1 may define a novel class of bifunctional transcriptional intermediary factors playing distinct roles in both the presence and absence of ligand."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/17.12.3398"xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/17.12.3398"xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/author | "Garnier J.-M."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/author | "Garnier J.-M."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/author | "Huang N."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/author | "Huang N."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/author | "Chambon P."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/author | "Chambon P."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/author | "Losson R."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/author | "Losson R."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/author | "Lutz Y."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/author | "Lutz Y."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/author | "Lerouge T."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/author | "Lerouge T."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/author | "Vonesch J.-L."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/author | "Vonesch J.-L."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/author | "vom Baur E."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/author | "vom Baur E."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/9628876 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |