| http://purl.uniprot.org/citations/9630224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9630224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9630224 | http://www.w3.org/2000/01/rdf-schema#comment | "We report the identification, characterization, and cloning of another novel Drosophila clock gene, cycle (cyc). Homozygous cyc flies are completely arrhythmic. Heterozygous cyc/+ flies are rhythmic but have altered periods, indicating that the cyc locus has a dosage effect on period. The molecular circadian phenotype of homozygous cyc flies is like homozygous Clk flies presented in the accompanying paper: mutant flies have little or no transcription of the per and tim genes. Cloning of the gene indicates that it also encodes a bHLH-PAS transcription factor and is a Drosophila homolog of the human protein BMAL1. cyc is a nonsense mutation, consistent with its strong loss-of-function phenotype. We propose that the CYC:CLK heterodimer binds to per and tim E boxes and makes a major contribution to the circadian transcription of Drosophila clock genes."xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81441-5"xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81441-5"xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/author | "Rosbash M."xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/author | "Rosbash M."xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/author | "So W.V."xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/author | "So W.V."xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/author | "Le M."xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/author | "Le M."xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/author | "Hall J.C."xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/author | "Hall J.C."xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/author | "Rutila J.E."xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/author | "Rutila J.E."xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/author | "Suri V."xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/author | "Suri V."xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/pages | "805-814"xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/pages | "805-814"xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/title | "CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless."xsd:string |
| http://purl.uniprot.org/citations/9630224 | http://purl.uniprot.org/core/title | "CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless."xsd:string |