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http://purl.uniprot.org/citations/9635433http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9635433http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9635433http://www.w3.org/2000/01/rdf-schema#comment"We describe a novel 25 kDa protein, geminin, which inhibits DNA replication and is degraded during the mitotic phase of the cell cycle. Geminin has a destruction box sequence and is ubiquitinated anaphase-promoting complex (APC) in vitro. In synchronized HeLa cells, geminin is absent during G1 phase, accumulates during S, G2, and M phases, and disappears at the time of the metaphase-anaphase transition. Geminin inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex (pre-RC). We propose that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle."xsd:string
http://purl.uniprot.org/citations/9635433http://purl.org/dc/terms/identifier"doi:10.1016/s0092-8674(00)81209-x"xsd:string
http://purl.uniprot.org/citations/9635433http://purl.org/dc/terms/identifier"doi:10.1016/s0092-8674(00)81209-x"xsd:string
http://purl.uniprot.org/citations/9635433http://purl.org/dc/terms/identifier"doi:10.1016/S0092-8674(00)81209-X"xsd:string
http://purl.uniprot.org/citations/9635433http://purl.uniprot.org/core/author"Kirschner M.W."xsd:string
http://purl.uniprot.org/citations/9635433http://purl.uniprot.org/core/author"Kirschner M.W."xsd:string
http://purl.uniprot.org/citations/9635433http://purl.uniprot.org/core/author"McGarry T.J."xsd:string
http://purl.uniprot.org/citations/9635433http://purl.uniprot.org/core/author"McGarry T.J."xsd:string
http://purl.uniprot.org/citations/9635433http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9635433http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9635433http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/9635433http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/9635433http://purl.uniprot.org/core/pages"1043-1053"xsd:string
http://purl.uniprot.org/citations/9635433http://purl.uniprot.org/core/pages"1043-1053"xsd:string
http://purl.uniprot.org/citations/9635433http://purl.uniprot.org/core/title"Geminin, an inhibitor of DNA replication, is degraded during mitosis."xsd:string
http://purl.uniprot.org/citations/9635433http://purl.uniprot.org/core/title"Geminin, an inhibitor of DNA replication, is degraded during mitosis."xsd:string
http://purl.uniprot.org/citations/9635433http://purl.uniprot.org/core/volume"93"xsd:string
http://purl.uniprot.org/citations/9635433http://purl.uniprot.org/core/volume"93"xsd:string
http://purl.uniprot.org/citations/9635433http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9635433
http://purl.uniprot.org/citations/9635433http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9635433
http://purl.uniprot.org/citations/9635433http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9635433
http://purl.uniprot.org/citations/9635433http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9635433
http://purl.uniprot.org/uniprot/O93355http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/9635433