| http://purl.uniprot.org/citations/9636086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9636086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9636086 | http://www.w3.org/2000/01/rdf-schema#comment | "Within a developing organism, cells receive many signals which control their proliferation, fate specification and differentiation. One group of such proteins is the TGF-beta/BMP class of related signaling molecules. Based on expression studies, multiple members of this class of ligands must impinge upon the same cells of a developing tissue; however, the role that multiple TGF-beta/BMP ligands may play in directing the development of such a tissue is not understood. Here we provide evidence that multiple BMPs are required for growth and patterning of the Drosophila wing. The Drosophila BMP gene, gbb-60A, exhibits a requirement in wing morphogenesis distinct from that shown previously for dpp, a well-characterized Drosophila BMP member. gbb-60A mutants exhibit a loss of pattern elements from the wing, particularly those derived from cells in the posterior compartment, consistent with the gbb-60A RNA and protein expression pattern. Based on genetic analysis and expression studies, we conclude that Gbb-60A must signal primarily as a homodimer to provide patterning information in the wing imaginal disc. We demonstrate that gbb-60A and dpp genetically interact and that specific aspects of this interaction are synergistic while others are antagonistic. We propose that the positional information received by a cell at a particular location within the wing imaginal disc depends on the balance of Dpp to Gbb-60A signaling. Furthermore, the critical ratio of Gbb-60A to Dpp signaling appears to be mediated by both Tkv and Sax type I receptors."xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.125.14.2723"xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.125.14.2723"xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/author | "Khalsa O."xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/author | "Khalsa O."xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/author | "Torres-Schumann S."xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/author | "Torres-Schumann S."xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/author | "Wharton K.A."xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/author | "Wharton K.A."xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/author | "Yoon J.-W."xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/author | "Yoon J.-W."xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/pages | "2723-2734"xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/pages | "2723-2734"xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/title | "TGF-beta/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing."xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/title | "TGF-beta/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing."xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/9636086 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9636086 |
| http://purl.uniprot.org/citations/9636086 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9636086 |