| http://purl.uniprot.org/citations/9647219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9647219 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have suggested that oral tolerance induction by low doses of Ag is mediated by inhibitory cytokines, particularly TGF-beta 1. To examine the roles of TGF-beta 1 and other inhibitory cytokines in the induction of oral tolerance, TGF-beta 1 null mice and controls were gavaged with 10 to 20 mg (high dose) or 1 mg (low dose) of OVA for 3 days. After immunization with OVA, the in vitro proliferative response of OVA-specific popliteal lymph node cells was assessed. Lymphocytes from all TGF-beta 1 null mice fed high doses of OVA exhibited highly significant suppression compared with controls. A weaker, but still significant, suppression was observed in lymphocytes from the majority of TGF-beta 1 null mice fed low doses of OVA. In addition, supernatants from these lymphocytes exhibited lower levels of IL-4, IL-10, and IFN-gamma than those from water-fed control animals. These results indicate that while TGF-beta 1 may play a role in suppression, inhibitory cytokines are not the exclusive mechanism by which low dose oral tolerance is induced."xsd:string |
| http://purl.uniprot.org/citations/9647219 | http://purl.uniprot.org/core/author | "Doetschman T."xsd:string |
| http://purl.uniprot.org/citations/9647219 | http://purl.uniprot.org/core/author | "Ormsby I."xsd:string |
| http://purl.uniprot.org/citations/9647219 | http://purl.uniprot.org/core/author | "Barone K.S."xsd:string |
| http://purl.uniprot.org/citations/9647219 | http://purl.uniprot.org/core/author | "Michael J.G."xsd:string |
| http://purl.uniprot.org/citations/9647219 | http://purl.uniprot.org/core/author | "Tolarova D.D."xsd:string |
| http://purl.uniprot.org/citations/9647219 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9647219 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/9647219 | http://purl.uniprot.org/core/pages | "154-160"xsd:string |
| http://purl.uniprot.org/citations/9647219 | http://purl.uniprot.org/core/title | "Induction of oral tolerance in TGF-beta 1 null mice."xsd:string |
| http://purl.uniprot.org/citations/9647219 | http://purl.uniprot.org/core/volume | "161"xsd:string |
| http://purl.uniprot.org/citations/9647219 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9647219 |
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| http://purl.uniprot.org/uniprot/#_E9Q6I6-mappedCitation-9647219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9647219 |
| http://purl.uniprot.org/uniprot/#_P04202-mappedCitation-9647219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9647219 |
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| http://purl.uniprot.org/uniprot/P04202 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9647219 |
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