| http://purl.uniprot.org/citations/9648857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9648857 | http://www.w3.org/2000/01/rdf-schema#comment | "Human NT2-N neurons express Ca2+-permeable alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid glutamate receptors (AMPA-GluRs) and become vulnerable to excitotoxicity when AMPA-GluR desensitization is blocked with cyclothiazide. Although the initial increase in intracellular Ca2+ levels ([Ca2+]i) was 1.9-fold greater in the presence than in the absence of cyclothiazide, Ca2+ entry via AMPA-GluRs in an early phase of the exposure was not necessary to elicit excitotoxicity in these neurons. Rather, subsequent necrosis was caused by a >40-fold rise in [Na+]i, which induced a delayed [Ca2+]i rise. Transfer of the neurons to a 5 mM Na+ medium after AMPA-GluR activation accelerated the delayed [Ca2+]i rise and intensified excitotoxicity. Low-Na+ medium-enhanced excitotoxicity was partially blocked by amiloride or dizocilpine (MK-801), and completely blocked by removal of extracellular Ca2+, suggesting that Ca2+ entry by reverse operation of Na+/Ca2+ exchangers and via NMDA glutamate receptors was responsible for the neuronal death after excessive Na+ loading. Our results serve to emphasize the central role of neuronal Na+ loading in AMPA-GluR-mediated excitotoxicity in human neurons."xsd:string |
| http://purl.uniprot.org/citations/9648857 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1471-4159.1998.71010112.x"xsd:string |
| http://purl.uniprot.org/citations/9648857 | http://purl.uniprot.org/core/author | "Itoh T."xsd:string |
| http://purl.uniprot.org/citations/9648857 | http://purl.uniprot.org/core/author | "Itoh A."xsd:string |
| http://purl.uniprot.org/citations/9648857 | http://purl.uniprot.org/core/author | "Horiuchi K."xsd:string |
| http://purl.uniprot.org/citations/9648857 | http://purl.uniprot.org/core/author | "Pleasure D."xsd:string |
| http://purl.uniprot.org/citations/9648857 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9648857 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/9648857 | http://purl.uniprot.org/core/pages | "112-124"xsd:string |
| http://purl.uniprot.org/citations/9648857 | http://purl.uniprot.org/core/title | "AMPA receptor-mediated excitotoxicity in human NT2-N neurons results from loss of intracellular Ca2+ homeostasis following marked elevation of intracellular Na+."xsd:string |
| http://purl.uniprot.org/citations/9648857 | http://purl.uniprot.org/core/volume | "71"xsd:string |
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