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http://purl.uniprot.org/citations/9653119http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9653119http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9653119http://www.w3.org/2000/01/rdf-schema#comment"Cognate cDNAs are described for 2 of the 10 thyroid hormone receptor-associated proteins (TRAPs) that are immunopurified with thyroid hormone receptor alpha (TRalpha) from ligand-treated HeLa (alpha-2) cells. Both TRAP220 and TRAP100 contain LXXLL domains found in other nuclear receptor-interacting proteins and both appear to reside in a single complex with other TRAPs (in the absence of TR). However, only TRAP220 shows a direct ligand-dependent interaction with TRalpha, and these interactions are mediated through the C terminus of TRalpha and (at least in part) the LXXLL domains of TRAP220. TRAP220 also interacts with other nuclear receptors [vitamin D receptor, retinoic acid receptor alpha, retinoid X receptor alpha, peroxisome proliferation-activated receptor (PPAR) alpha, PPARgamma and, to a lesser extent, estrogen receptor] in a ligand-dependent manner, whereas TRAP100 shows only marginal interactions with estrogen receptor, retinoid X receptor alpha, PPARalpha, and PPARgamma. Consistent with these results, TRAP220 moderately stimulates human TRalpha-mediated transcription in transfected cells, whereas a fragment containing the LXXLL motifs acts as a dominant negative inhibitor of nuclear receptor-mediated transcription both in transfected cells (TRalpha) and in cell free transcription systems (TRalpha and vitamin D receptor). These studies indicate that TRAP220 plays a major role in anchoring other TRAPs to TRalpha during the function of the TRalpha-TRAP complex and, further, that TRAP220 (possibly along with other TRAPs) may be a global coactivator for the nuclear receptor superfamily."xsd:string
http://purl.uniprot.org/citations/9653119http://purl.org/dc/terms/identifier"doi:10.1073/pnas.95.14.7939"xsd:string
http://purl.uniprot.org/citations/9653119http://purl.org/dc/terms/identifier"doi:10.1073/pnas.95.14.7939"xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/author"Ito M."xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/author"Ito M."xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/author"Roeder R.G."xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/author"Roeder R.G."xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/author"Fondell J.D."xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/author"Fondell J.D."xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/author"Yuan C.-X."xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/author"Yuan C.-X."xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/author"Fu Z.-Y."xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/author"Fu Z.-Y."xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/pages"7939-7944"xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/pages"7939-7944"xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/title"The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion."xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/title"The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion."xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/volume"95"xsd:string
http://purl.uniprot.org/citations/9653119http://purl.uniprot.org/core/volume"95"xsd:string
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