| http://purl.uniprot.org/citations/9655116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9655116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9655116 | http://www.w3.org/2000/01/rdf-schema#comment | "Golden retriever muscular dystrophy (GRMD), the canine model of Duchenne muscular dystrophy (DMD), is caused by a splice site mutation in the dystrophin gene. This mutation predicts a premature termination codon in exon 8 and a peptide that is 5% the size of normal dystrophin. Western blot analysis of skeletal muscle from GRMD dogs reveals a slightly truncated 390-kD protein that is approximately 91% the size of normal dystrophin. This 390-kD dystrophin suggests that GRMD dogs, like some DMD patients, employ a mechanism to overcome their predicted frameshift. Reverse-transcriptase polymerase chain reaction on GRMD muscle has revealed two in-frame dystrophin transcripts which lack either exons 3-9 or exons 5-12. Both transcripts could be translated into a dystrophin protein of approximately 390 kD. An understanding of how truncated dystrophin is produced in GRMD may allow this mechanism to be manipulated toward a potential therapy for DMD."xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.org/dc/terms/identifier | "doi:10.1002/(sici)1097-4598(199808)21:8<991::aid-mus2>3.0.co;2-0"xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.org/dc/terms/identifier | "doi:10.1002/(sici)1097-4598(199808)21:8<991::aid-mus2>3.0.co;2-0"xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/author | "Mann C.J."xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/author | "Mann C.J."xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/author | "Anderson L.V."xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/author | "Anderson L.V."xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/author | "Kornegay J.N."xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/author | "Kornegay J.N."xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/author | "Schatzberg S.J."xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/author | "Schatzberg S.J."xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/author | "Sharp N.J."xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/author | "Sharp N.J."xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/author | "Solomon G.G."xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/author | "Solomon G.G."xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/author | "Wilton S.D."xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/author | "Wilton S.D."xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/name | "Muscle Nerve"xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/name | "Muscle Nerve"xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/pages | "991-998"xsd:string |
| http://purl.uniprot.org/citations/9655116 | http://purl.uniprot.org/core/pages | "991-998"xsd:string |